Herpesvirus infection of seborrheic keratoses

Research output: Contribution to journalArticle

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Abstract

We present three examples of patients with seborrheic keratoses complicated by necrotizing herpesvirus infection. Two patients had localized cutaneous herpetic infections, and the third patient had a generalized cutaneous herpesvirus infection. Two of the lesions were thought to be squamous cell carcinoma. The third was clinically identified as inflamed seborrheic keratosis. Herpes virus infection was not clinically suspected in two of the patients. The histologic changes were similar in all cases. Epidermal proliferation was accompanied by hyperkeratosis and pseudo horn cyst formation. Extensive keratinocyte necrosis was present along with balloon degeneration of keratinocytes, herpetic viral inclusions, and multinucleated giant cells. Viral lesions of molluscum contagiosum and human papillomavirus have been observed in benign skin proliferations. Nevertheless, we were unable to find descriptions of herpesvirus involvement in seborrheic keratosis in a Medline search. Necrotic seborrheic keratoses should be carefully examined for the possibility of herpesvirus infection, a condition that may be improved by prompt medical intervention as demonstrated in one of our cases.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalAmerican Journal of Dermatopathology
Volume23
Issue number2
DOIs
StatePublished - Apr 28 2001

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Seborrheic Keratosis
Herpesviridae Infections
Keratinocytes
Skin
Molluscum Contagiosum
Herpesviridae
Virus Diseases
Giant Cells
Horns
Cysts
Squamous Cell Carcinoma
Necrosis
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Herpesvirus infection of seborrheic keratoses. / Googe, Paul; King, Roy.

In: American Journal of Dermatopathology, Vol. 23, No. 2, 28.04.2001, p. 146-148.

Research output: Contribution to journalArticle

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