Heterotransplantation of human neoplasms

B. J. Jaffrey, S. V. Lair, John Hudson, B. B. Lozzio, E. A. Machado, D. C. Chase

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Transplantations of 39 human solid tumours were performed, with successful growth into immunosuppressed murine hosts in 28 cases. Two congenitally immunodeficient mouse strains were used: athymic (Nude) and athymic and asplenic (Lasat), with both newborn and adult mice hosts. In addition to initial transplantation, 17 tumour types could be transplanted successfully in serial passage in host mice. All tumours maintained histological fidelity with the original tumour, both in initial and serial transplants. Malignant melanomas and colorectal carcinomas grew well in immunosuppressed host mice. The use of newborn mice enhanced a more rapid growth of melanoma transplants than did adult mice.

Original languageEnglish (US)
Pages (from-to)16-20
Number of pages5
JournalJournal of Oral Surgery
Volume37
Issue number1
StatePublished - 1979

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Neoplasms
Immunocompromised Host
Melanoma
Transplantation
Serial Passage
Transplants
Growth
Colorectal Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Medicine(all)

Cite this

Jaffrey, B. J., Lair, S. V., Hudson, J., Lozzio, B. B., Machado, E. A., & Chase, D. C. (1979). Heterotransplantation of human neoplasms. Journal of Oral Surgery, 37(1), 16-20.

Heterotransplantation of human neoplasms. / Jaffrey, B. J.; Lair, S. V.; Hudson, John; Lozzio, B. B.; Machado, E. A.; Chase, D. C.

In: Journal of Oral Surgery, Vol. 37, No. 1, 1979, p. 16-20.

Research output: Contribution to journalArticle

Jaffrey, BJ, Lair, SV, Hudson, J, Lozzio, BB, Machado, EA & Chase, DC 1979, 'Heterotransplantation of human neoplasms', Journal of Oral Surgery, vol. 37, no. 1, pp. 16-20.
Jaffrey BJ, Lair SV, Hudson J, Lozzio BB, Machado EA, Chase DC. Heterotransplantation of human neoplasms. Journal of Oral Surgery. 1979;37(1):16-20.
Jaffrey, B. J. ; Lair, S. V. ; Hudson, John ; Lozzio, B. B. ; Machado, E. A. ; Chase, D. C. / Heterotransplantation of human neoplasms. In: Journal of Oral Surgery. 1979 ; Vol. 37, No. 1. pp. 16-20.
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