High-flux dialysis lowers plasma leptin concentration in chronic dialysis patients

D. W. Coyne, Samuel Dagogo-Jack, S. Klein, E. Merabet, J. Audrain, M. Landt

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Leptin is a protein produced by fat cells and involved in body weight regulation. Plasma leptin is significantly higher in some hemodialysis (HD) patients than in normal controls. We examined the influence of dialyzer membrane biocompatibility and flux on elevated plasma leptin concentrations in hemodialysis patients. Employing a crossover design, leptin and tumor necrosis factor α (TNFα) levels were serially determined in eight chronic dialysis patients. Patients were dialyzed sequentially on low-flux cellulosic (TAF) dialyzers, low-flux (F8) polysulfone, high-flux (F80B) polysulfone, then low-flux polysulfone and cellulosic dialyzers again. Mean leptin concentrations were similar when low-flux polysulfone or cellulosic dialyzers were employed (141.9 ± 24.2 μg/L versus 137.8 ± 18.4 μg/L, respectively (P = Ns). In contrast, leptin fell significantly on the high-flux polysulfone dialyzer (99.4 ± 16.2 μg/L) compared with cellulosic (P < 0.005), and low- flux polysulfone dialyzers (P < 0.02). Leptin clearance by the high-flux polysulfone dialyzer was significantly higher than the low-flux dialyzers (50.4 ± 21.5 v -9.6 ± 10.3 mL/min; P = 0.043), but did not account fully for the 30% decline in plasma leptin during the high-flux arm of the study. Concentrations of TNFα were lower when high-flux polysuifone dialyzers were employed, but there was no correlation of individual TNFα levels with leptin concentrations. High-flux dialysis lowers plasma leptin concentrations an average of 30%, but biocompatibility does not influence leptin levels. The decrease in plasma leptin on high-flux dialysis cannot be explained solely by enhanced clearance.

Original languageEnglish (US)
Pages (from-to)1031-1035
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume32
Issue number6
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

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Leptin
Dialysis
Tumor Necrosis Factor-alpha
Renal Dialysis
polysulfone P 1700
Adipocytes
Cross-Over Studies
Body Weight

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

High-flux dialysis lowers plasma leptin concentration in chronic dialysis patients. / Coyne, D. W.; Dagogo-Jack, Samuel; Klein, S.; Merabet, E.; Audrain, J.; Landt, M.

In: American Journal of Kidney Diseases, Vol. 32, No. 6, 01.01.1998, p. 1031-1035.

Research output: Contribution to journalArticle

Coyne, D. W. ; Dagogo-Jack, Samuel ; Klein, S. ; Merabet, E. ; Audrain, J. ; Landt, M. / High-flux dialysis lowers plasma leptin concentration in chronic dialysis patients. In: American Journal of Kidney Diseases. 1998 ; Vol. 32, No. 6. pp. 1031-1035.
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