High-frequency ventilation in the treatment of infants weighing less than 1,500 grams with pulmonary interstitial emphysema

A pilot study

Mark Gaylord, B. J. Quissell, M. E. Lair

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Pulmonary interstitial emphysema is one of the most serious complications of the respiratory distress syndrome. Its presence significantly increases morbidity and mortality. Preliminary reports have demonstrated the success of high-frequency ventilation in the treatment of pulmonary interstitial emphysema. In a previous investigation, we were able to develop a formula for predicting death in infants weighing less than 1,500 g with pulmonary interstitial emphysema. Using this subgroup of severely affected infants, we studied the efficacy of high-frequency ventilation in nine infants. Using the Volumetric Diffusive Respirator, we observed improvement in all respiratory values measured (pH, PCO2, and PO2), a significantly decreased mean airway pressure (MAP), and improvement in neonatal mortality. Complications of severe bleeding diatheses, hypotension, bronchopulmonary dysplasia, and necrotizing tracheobronchitis were observed. Our investigation was the first to systematically choose infants who might benefit from high-frequency ventilation and to compare them with similar infants with known outcomes. We realize that the study was rescue in nature using historical controls, but we felt compelled to assure the safety of the device before randomizing less sick infants. High-frequency ventilation appears to be effective in the acute management of low birth weight infants with pulmonary interstitial emphysema.

Original languageEnglish (US)
Pages (from-to)915-921
Number of pages7
JournalPediatrics
Volume79
Issue number6
StatePublished - 1987
Externally publishedYes

Fingerprint

High-Frequency Ventilation
Pulmonary Emphysema
Protective Devices
Therapeutics
Bronchopulmonary Dysplasia
Disease Susceptibility
Infant Mortality
Low Birth Weight Infant
Mechanical Ventilators
Hypotension
Hemorrhage
Morbidity
Pressure
Mortality

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

High-frequency ventilation in the treatment of infants weighing less than 1,500 grams with pulmonary interstitial emphysema : A pilot study. / Gaylord, Mark; Quissell, B. J.; Lair, M. E.

In: Pediatrics, Vol. 79, No. 6, 1987, p. 915-921.

Research output: Contribution to journalArticle

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