High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese

Yue Huang, Jing Jing, Xing Quan Zhao, Chun Xue Wang, Yi Long Wang, Gai Fen Liu, Chun Juan Wang, Li Ping Liu, Xiao Meng Yang, Yan Jiao, Yun Jiao, Li Shi Wang, Yong Jun Wang, Weikuan Gu

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Abstract

Background and purpose: Elevated plasma C-reactive protein (CRP) has been suggested as a risk factor for ischemic stroke (IS) and coronary ischemic disease. Evidence has shown that high-sensitivity CRP (hs-CRP) is related to a worsening prognosis after IS, but hs-CRP was rare in a large-sample study in a Chinese population. We investigated the associations between hs-CRP and outcome of Chinese patients after acute IS. Methods: Seven hundred and forty-one consecutive acute IS patients (74.9% male, mean age 60.9 years), with baseline characteristics and hs-CRP measured within 24 h after hospitalization, were admitted in this study. We also prospectively followed up for clinical outcome and death 3 months after disease onset. hs-CRP was divided into two categories: hs-CRP >3 mg/L and hs-CRP ≤3 mg/L. Survival analysis using multivariable Cox regression was performed to analyze the association between hs-CRP and stroke outcomes after adjusting for potential confounding factors. Results: Compared with low hs-CRP, patients with high hs-CRP (>3 mg/L) had a significantly higher rate of all-cause death (0.71% vs. 10.00%; P < 0.001) at 3 months after stroke onset. High hs-CRP was an independent risk factor for all-cause death (HR, 6.48; 95% CI, 1.41 to 29.8; P= 0.016), as well as history of atrial fibrillation (HR, 5.24; 95% CI, 1.83 to 15.0; P= 0.002), no statin therapy during hospitalization (HR, 4.56; 95% CI, 2.18 to 9.55; P < 0.001), high homocysteine (>15.1 mmol/L) (HR, 2.66; 95% CI, 1.26 to 5.60; P= 0.01); fasting glucose (>6.1 mmol/L) (HR, 9.14; 95% CI, 3.34 to 25.0; P < 0.001), NIHSS at admission (HR, 2.35; 95% CI, 1.35 to 4.09; P= 0.003) and history of coronary heart disease (CHD) (HR, 2.34; 95% CI, 1.06 to 5.17; P= 0.035). Kaplan-Meier survival curves showed a higher risk of death for patients with hs-CRP >3 mg/L (P= 0.016). Conclusion: Elevated plasma hs-CRP independently predicted risk of all-cause death within 3 months after acute IS in Chinese patients.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalCNS Neuroscience and Therapeutics
Volume18
Issue number3
DOIs
StatePublished - Mar 1 2012

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C-Reactive Protein
Stroke
Cause of Death
Survival Analysis
Coronary Disease
Blood Proteins
Fasting
Hospitalization
Glucose
Population

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)

Cite this

High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese. / Huang, Yue; Jing, Jing; Zhao, Xing Quan; Wang, Chun Xue; Wang, Yi Long; Liu, Gai Fen; Wang, Chun Juan; Liu, Li Ping; Yang, Xiao Meng; Jiao, Yan; Jiao, Yun; Wang, Li Shi; Wang, Yong Jun; Gu, Weikuan.

In: CNS Neuroscience and Therapeutics, Vol. 18, No. 3, 01.03.2012, p. 261-266.

Research output: Contribution to journalArticle

Huang, Y, Jing, J, Zhao, XQ, Wang, CX, Wang, YL, Liu, GF, Wang, CJ, Liu, LP, Yang, XM, Jiao, Y, Jiao, Y, Wang, LS, Wang, YJ & Gu, W 2012, 'High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese', CNS Neuroscience and Therapeutics, vol. 18, no. 3, pp. 261-266. https://doi.org/10.1111/j.1755-5949.2012.00296.x
Huang, Yue ; Jing, Jing ; Zhao, Xing Quan ; Wang, Chun Xue ; Wang, Yi Long ; Liu, Gai Fen ; Wang, Chun Juan ; Liu, Li Ping ; Yang, Xiao Meng ; Jiao, Yan ; Jiao, Yun ; Wang, Li Shi ; Wang, Yong Jun ; Gu, Weikuan. / High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese. In: CNS Neuroscience and Therapeutics. 2012 ; Vol. 18, No. 3. pp. 261-266.
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title = "High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese",
abstract = "Background and purpose: Elevated plasma C-reactive protein (CRP) has been suggested as a risk factor for ischemic stroke (IS) and coronary ischemic disease. Evidence has shown that high-sensitivity CRP (hs-CRP) is related to a worsening prognosis after IS, but hs-CRP was rare in a large-sample study in a Chinese population. We investigated the associations between hs-CRP and outcome of Chinese patients after acute IS. Methods: Seven hundred and forty-one consecutive acute IS patients (74.9{\%} male, mean age 60.9 years), with baseline characteristics and hs-CRP measured within 24 h after hospitalization, were admitted in this study. We also prospectively followed up for clinical outcome and death 3 months after disease onset. hs-CRP was divided into two categories: hs-CRP >3 mg/L and hs-CRP ≤3 mg/L. Survival analysis using multivariable Cox regression was performed to analyze the association between hs-CRP and stroke outcomes after adjusting for potential confounding factors. Results: Compared with low hs-CRP, patients with high hs-CRP (>3 mg/L) had a significantly higher rate of all-cause death (0.71{\%} vs. 10.00{\%}; P < 0.001) at 3 months after stroke onset. High hs-CRP was an independent risk factor for all-cause death (HR, 6.48; 95{\%} CI, 1.41 to 29.8; P= 0.016), as well as history of atrial fibrillation (HR, 5.24; 95{\%} CI, 1.83 to 15.0; P= 0.002), no statin therapy during hospitalization (HR, 4.56; 95{\%} CI, 2.18 to 9.55; P < 0.001), high homocysteine (>15.1 mmol/L) (HR, 2.66; 95{\%} CI, 1.26 to 5.60; P= 0.01); fasting glucose (>6.1 mmol/L) (HR, 9.14; 95{\%} CI, 3.34 to 25.0; P < 0.001), NIHSS at admission (HR, 2.35; 95{\%} CI, 1.35 to 4.09; P= 0.003) and history of coronary heart disease (CHD) (HR, 2.34; 95{\%} CI, 1.06 to 5.17; P= 0.035). Kaplan-Meier survival curves showed a higher risk of death for patients with hs-CRP >3 mg/L (P= 0.016). Conclusion: Elevated plasma hs-CRP independently predicted risk of all-cause death within 3 months after acute IS in Chinese patients.",
author = "Yue Huang and Jing Jing and Zhao, {Xing Quan} and Wang, {Chun Xue} and Wang, {Yi Long} and Liu, {Gai Fen} and Wang, {Chun Juan} and Liu, {Li Ping} and Yang, {Xiao Meng} and Yan Jiao and Yun Jiao and Wang, {Li Shi} and Wang, {Yong Jun} and Weikuan Gu",
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T1 - High-Sensitivity C-Reactive Protein is a Strong Risk Factor for Death after Acute Ischemic Stroke among Chinese

AU - Huang, Yue

AU - Jing, Jing

AU - Zhao, Xing Quan

AU - Wang, Chun Xue

AU - Wang, Yi Long

AU - Liu, Gai Fen

AU - Wang, Chun Juan

AU - Liu, Li Ping

AU - Yang, Xiao Meng

AU - Jiao, Yan

AU - Jiao, Yun

AU - Wang, Li Shi

AU - Wang, Yong Jun

AU - Gu, Weikuan

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Background and purpose: Elevated plasma C-reactive protein (CRP) has been suggested as a risk factor for ischemic stroke (IS) and coronary ischemic disease. Evidence has shown that high-sensitivity CRP (hs-CRP) is related to a worsening prognosis after IS, but hs-CRP was rare in a large-sample study in a Chinese population. We investigated the associations between hs-CRP and outcome of Chinese patients after acute IS. Methods: Seven hundred and forty-one consecutive acute IS patients (74.9% male, mean age 60.9 years), with baseline characteristics and hs-CRP measured within 24 h after hospitalization, were admitted in this study. We also prospectively followed up for clinical outcome and death 3 months after disease onset. hs-CRP was divided into two categories: hs-CRP >3 mg/L and hs-CRP ≤3 mg/L. Survival analysis using multivariable Cox regression was performed to analyze the association between hs-CRP and stroke outcomes after adjusting for potential confounding factors. Results: Compared with low hs-CRP, patients with high hs-CRP (>3 mg/L) had a significantly higher rate of all-cause death (0.71% vs. 10.00%; P < 0.001) at 3 months after stroke onset. High hs-CRP was an independent risk factor for all-cause death (HR, 6.48; 95% CI, 1.41 to 29.8; P= 0.016), as well as history of atrial fibrillation (HR, 5.24; 95% CI, 1.83 to 15.0; P= 0.002), no statin therapy during hospitalization (HR, 4.56; 95% CI, 2.18 to 9.55; P < 0.001), high homocysteine (>15.1 mmol/L) (HR, 2.66; 95% CI, 1.26 to 5.60; P= 0.01); fasting glucose (>6.1 mmol/L) (HR, 9.14; 95% CI, 3.34 to 25.0; P < 0.001), NIHSS at admission (HR, 2.35; 95% CI, 1.35 to 4.09; P= 0.003) and history of coronary heart disease (CHD) (HR, 2.34; 95% CI, 1.06 to 5.17; P= 0.035). Kaplan-Meier survival curves showed a higher risk of death for patients with hs-CRP >3 mg/L (P= 0.016). Conclusion: Elevated plasma hs-CRP independently predicted risk of all-cause death within 3 months after acute IS in Chinese patients.

AB - Background and purpose: Elevated plasma C-reactive protein (CRP) has been suggested as a risk factor for ischemic stroke (IS) and coronary ischemic disease. Evidence has shown that high-sensitivity CRP (hs-CRP) is related to a worsening prognosis after IS, but hs-CRP was rare in a large-sample study in a Chinese population. We investigated the associations between hs-CRP and outcome of Chinese patients after acute IS. Methods: Seven hundred and forty-one consecutive acute IS patients (74.9% male, mean age 60.9 years), with baseline characteristics and hs-CRP measured within 24 h after hospitalization, were admitted in this study. We also prospectively followed up for clinical outcome and death 3 months after disease onset. hs-CRP was divided into two categories: hs-CRP >3 mg/L and hs-CRP ≤3 mg/L. Survival analysis using multivariable Cox regression was performed to analyze the association between hs-CRP and stroke outcomes after adjusting for potential confounding factors. Results: Compared with low hs-CRP, patients with high hs-CRP (>3 mg/L) had a significantly higher rate of all-cause death (0.71% vs. 10.00%; P < 0.001) at 3 months after stroke onset. High hs-CRP was an independent risk factor for all-cause death (HR, 6.48; 95% CI, 1.41 to 29.8; P= 0.016), as well as history of atrial fibrillation (HR, 5.24; 95% CI, 1.83 to 15.0; P= 0.002), no statin therapy during hospitalization (HR, 4.56; 95% CI, 2.18 to 9.55; P < 0.001), high homocysteine (>15.1 mmol/L) (HR, 2.66; 95% CI, 1.26 to 5.60; P= 0.01); fasting glucose (>6.1 mmol/L) (HR, 9.14; 95% CI, 3.34 to 25.0; P < 0.001), NIHSS at admission (HR, 2.35; 95% CI, 1.35 to 4.09; P= 0.003) and history of coronary heart disease (CHD) (HR, 2.34; 95% CI, 1.06 to 5.17; P= 0.035). Kaplan-Meier survival curves showed a higher risk of death for patients with hs-CRP >3 mg/L (P= 0.016). Conclusion: Elevated plasma hs-CRP independently predicted risk of all-cause death within 3 months after acute IS in Chinese patients.

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