Higher inflammatory marker levels in older persons

Associations with 5-year change in muscle mass and muscle strength

Laura A. Schaap, Saskia M.F. Pluijm, Dorly J.H. Deeg, Tamara B. Harris, Stephen B. Kritchevsky, Anne B. Newman, Lisa H. Colbert, Marco Pahor, Susan M. Rubin, Frances Tylavsky, Marjolein Visser

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

Background. There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association, between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods. Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results. Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions. TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.

Original languageEnglish (US)
Pages (from-to)1183-1189
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number11
DOIs
StatePublished - Dec 1 2009

Fingerprint

Muscle Strength
Tumor Necrosis Factor-alpha
Hand Strength
Muscles
Thigh
Weights and Measures
Sarcopenia
Interleukin-6 Receptors
Women's Health
Body Composition
Serum
C-Reactive Protein
Interleukin-6
Knee
Tomography
Inflammation

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Higher inflammatory marker levels in older persons : Associations with 5-year change in muscle mass and muscle strength. / Schaap, Laura A.; Pluijm, Saskia M.F.; Deeg, Dorly J.H.; Harris, Tamara B.; Kritchevsky, Stephen B.; Newman, Anne B.; Colbert, Lisa H.; Pahor, Marco; Rubin, Susan M.; Tylavsky, Frances; Visser, Marjolein.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 64, No. 11, 01.12.2009, p. 1183-1189.

Research output: Contribution to journalArticle

Schaap, LA, Pluijm, SMF, Deeg, DJH, Harris, TB, Kritchevsky, SB, Newman, AB, Colbert, LH, Pahor, M, Rubin, SM, Tylavsky, F & Visser, M 2009, 'Higher inflammatory marker levels in older persons: Associations with 5-year change in muscle mass and muscle strength', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 64, no. 11, pp. 1183-1189. https://doi.org/10.1093/gerona/glp097
Schaap, Laura A. ; Pluijm, Saskia M.F. ; Deeg, Dorly J.H. ; Harris, Tamara B. ; Kritchevsky, Stephen B. ; Newman, Anne B. ; Colbert, Lisa H. ; Pahor, Marco ; Rubin, Susan M. ; Tylavsky, Frances ; Visser, Marjolein. / Higher inflammatory marker levels in older persons : Associations with 5-year change in muscle mass and muscle strength. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2009 ; Vol. 64, No. 11. pp. 1183-1189.
@article{c45db7b8e7b24c9691400774ed5c4aee,
title = "Higher inflammatory marker levels in older persons: Associations with 5-year change in muscle mass and muscle strength",
abstract = "Background. There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association, between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods. Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results. Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions. TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.",
author = "Schaap, {Laura A.} and Pluijm, {Saskia M.F.} and Deeg, {Dorly J.H.} and Harris, {Tamara B.} and Kritchevsky, {Stephen B.} and Newman, {Anne B.} and Colbert, {Lisa H.} and Marco Pahor and Rubin, {Susan M.} and Frances Tylavsky and Marjolein Visser",
year = "2009",
month = "12",
day = "1",
doi = "10.1093/gerona/glp097",
language = "English (US)",
volume = "64",
pages = "1183--1189",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Higher inflammatory marker levels in older persons

T2 - Associations with 5-year change in muscle mass and muscle strength

AU - Schaap, Laura A.

AU - Pluijm, Saskia M.F.

AU - Deeg, Dorly J.H.

AU - Harris, Tamara B.

AU - Kritchevsky, Stephen B.

AU - Newman, Anne B.

AU - Colbert, Lisa H.

AU - Pahor, Marco

AU - Rubin, Susan M.

AU - Tylavsky, Frances

AU - Visser, Marjolein

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background. There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association, between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods. Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results. Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions. TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.

AB - Background. There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association, between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. Methods. Using data on 2,177 men and women in the Health, Aging, and Body Composition Study, we examined 5-year change in thigh muscle area estimated by computed tomography and grip and knee extensor strength in relation to serum levels of interleukin-6 (IL-6), C-reactive protein, tumor necrosis factor-alpha (TNF-α), and soluble receptors (measured in a subsample) at baseline. Results. Higher levels of inflammatory markers were generally associated with greater 5-year decline in thigh muscle area. Most associations, with the exception of soluble receptors, were attenuated by adjustment for 5-year change in weight. Higher TNF-α and interleukin-6 soluble receptor levels remained associated with greater decline in grip strength in men. Analyses in a subgroup of weight-stable persons showed that higher levels of TNF-α and its soluble receptors were associated with 5-year decline in thigh muscle area and that higher levels of TNF-α were associated with decline in grip strength. Conclusions. TNF-α and its soluble receptors showed the most consistent associations with decline in muscle mass and strength. The results suggest a weight-associated pathway for inflammation in sarcopenia.

UR - http://www.scopus.com/inward/record.url?scp=70350437283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350437283&partnerID=8YFLogxK

U2 - 10.1093/gerona/glp097

DO - 10.1093/gerona/glp097

M3 - Article

VL - 64

SP - 1183

EP - 1189

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 11

ER -