Higher recipient body mass index is associated with post-transplant delayed kidney graft function

Miklos Z. Molnar, Csaba Kovesdy, Istvan Mucsi, Suphamai Bunnapradist, Elani Streja, Mahesh Krishnan, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

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Abstract

To examine whether a higher body mass index (BMI) in kidney recipients is associated with delayed graft function (DGF), we analyzed data from 11,836 hemodialysis patients in the Scientific Registry of Transplant Recipients who underwent kidney transplantation. The patient cohort included women, blacks, and diabetics; the average age was 49 years; and the mean BMI was 26.8 kg/m 2. After adjusting for relevant covariates, multivariate logistic regression analyses found that one standard deviation increase in pretransplant BMI was associated with a higher risk of DGF (odds ratio (OR) 1.35). Compared with patients with a pretransplant BMI of 22-24.99 kg/m2, overweight patients (BMI 25-29.99 kg/m2), mild obesity patients (BMI 30-34.99 kg/m2), and moderate-to-severe obesity patients (BMI 35 kg/m 2 and over) had a significantly higher risk of DGF, with ORs of 1.30, 1.42, and 2.18, respectively. Similar associations were found in all subgroups of patients. Hence, pretransplant overweight or obesity is associated with an incrementally higher risk of DGF.

Original languageEnglish (US)
Pages (from-to)218-224
Number of pages7
JournalKidney International
Volume80
Issue number2
DOIs
StatePublished - Jul 2 2011
Externally publishedYes

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Delayed Graft Function
Body Mass Index
Transplants
Kidney
Obesity
Morbid Obesity
Kidney Transplantation
Registries
Renal Dialysis
Logistic Models
Odds Ratio
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Molnar, M. Z., Kovesdy, C., Mucsi, I., Bunnapradist, S., Streja, E., Krishnan, M., & Kalantar-Zadeh, K. (2011). Higher recipient body mass index is associated with post-transplant delayed kidney graft function. Kidney International, 80(2), 218-224. https://doi.org/10.1038/ki.2011.114

Higher recipient body mass index is associated with post-transplant delayed kidney graft function. / Molnar, Miklos Z.; Kovesdy, Csaba; Mucsi, Istvan; Bunnapradist, Suphamai; Streja, Elani; Krishnan, Mahesh; Kalantar-Zadeh, Kamyar.

In: Kidney International, Vol. 80, No. 2, 02.07.2011, p. 218-224.

Research output: Contribution to journalArticle

Molnar, MZ, Kovesdy, C, Mucsi, I, Bunnapradist, S, Streja, E, Krishnan, M & Kalantar-Zadeh, K 2011, 'Higher recipient body mass index is associated with post-transplant delayed kidney graft function', Kidney International, vol. 80, no. 2, pp. 218-224. https://doi.org/10.1038/ki.2011.114
Molnar, Miklos Z. ; Kovesdy, Csaba ; Mucsi, Istvan ; Bunnapradist, Suphamai ; Streja, Elani ; Krishnan, Mahesh ; Kalantar-Zadeh, Kamyar. / Higher recipient body mass index is associated with post-transplant delayed kidney graft function. In: Kidney International. 2011 ; Vol. 80, No. 2. pp. 218-224.
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