Hippocampal sclerosis and verbal encoding ability following anterior temporal lobectomy

Michael Seidenberg, Bruce P. Hermann, F Dohan, Allen R. Wyler, Alicia Perrine, Jen Schoenfeld

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Previous research has shown that the degree of verbal memory decline following left anterior temporal lobectomy (ATL) is inversely related to the extent of neuronal dropout in resected left hippocampus. The goal of this investigation was to clarify further the nature of the free recall impairment and to determine the relative contribution of verbal retrieval and encoding processes. Seventy-six patients who underwent left (n = 46) or right (n = 30) ATL were classified according to the presence or absence of hippocampal sclerosis and pre- to postoperative changes in free recall, cued recall and recognition memory for verbal material were examined. Surgically induced free recall impairments were selectively associated with resection of nonsclerotic left hippocampus and represented a 29-35% decline in verbal learning ability. These free recall deficits were due to postoperative impairment in verbal encoding efficiency, not retrieval difficulties. Assessment of false positive recognition errors indicated that resection of nonsclerotic left hippocampus selectively impaired the ability to encode stimulus uniqueness within correct semantic fields. The clinical and theoretical significance of these results are discussed.

Original languageEnglish (US)
Pages (from-to)699-708
Number of pages10
JournalNeuropsychologia
Volume34
Issue number7
DOIs
StatePublished - Jan 1 1996

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Anterior Temporal Lobectomy
Aptitude
Sclerosis
Hippocampus
Verbal Learning
Semantics
Efficiency
Research
Recognition (Psychology)

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Hippocampal sclerosis and verbal encoding ability following anterior temporal lobectomy. / Seidenberg, Michael; Hermann, Bruce P.; Dohan, F; Wyler, Allen R.; Perrine, Alicia; Schoenfeld, Jen.

In: Neuropsychologia, Vol. 34, No. 7, 01.01.1996, p. 699-708.

Research output: Contribution to journalArticle

Seidenberg, M, Hermann, BP, Dohan, F, Wyler, AR, Perrine, A & Schoenfeld, J 1996, 'Hippocampal sclerosis and verbal encoding ability following anterior temporal lobectomy', Neuropsychologia, vol. 34, no. 7, pp. 699-708. https://doi.org/10.1016/0028-3932(95)00146-8
Seidenberg, Michael ; Hermann, Bruce P. ; Dohan, F ; Wyler, Allen R. ; Perrine, Alicia ; Schoenfeld, Jen. / Hippocampal sclerosis and verbal encoding ability following anterior temporal lobectomy. In: Neuropsychologia. 1996 ; Vol. 34, No. 7. pp. 699-708.
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