Hippocampal theta rhythm is reduced by suppression of the H-current in septohippocampal GABAergic neurons

Changqing Xu, Subimal Datta, Min Wu, Meenakshi Alreja

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Hippocampal learning and memory tasks are tightly coupled to the hippocampal theta rhythm, which is critically dependent on the medial septum/diagonal band of Broca (MSDB) although the underlying mechanisms remain unclear. The MSDB sends both cholinergic and GABAergic projections to the hippocampus. Here we show that: (i) septo-hippocampal GABAergic but not cholinergic neurons have a pacemaking current, the H-current, and that its selective blockade by ZD7288 reduces their spontaneous firing in rat brain slices; and (ii), local infusions of ZD7288 into the MSDB reduce exploration and sensory evoked hippocampal theta bursts in behaving rats. Thus, the H-current in septohippocampal GABAergic neurons modulates the hippocampal theta rhythm.

Original languageEnglish (US)
Pages (from-to)2299-2309
Number of pages11
JournalEuropean Journal of Neuroscience
Volume19
Issue number8
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Fingerprint

Diagonal Band of Broca
Theta Rhythm
GABAergic Neurons
Cholinergic Neurons
Cholinergic Agents
Hippocampus
Learning
Brain
ICI D2788

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Hippocampal theta rhythm is reduced by suppression of the H-current in septohippocampal GABAergic neurons. / Xu, Changqing; Datta, Subimal; Wu, Min; Alreja, Meenakshi.

In: European Journal of Neuroscience, Vol. 19, No. 8, 01.04.2004, p. 2299-2309.

Research output: Contribution to journalArticle

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