Histologic variations in the epididymis

Findings in 167 orchiectomy specimens

Varsha I. Shah, Jae Y. Ro, Mahul Amin, Seema Mullick, Tipu Nazeer, Alberto G. Ayala

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Nonpathologic morphologic variations in the epididymal histology in 167 orchiectomy specimens were analyzed to assess and document the nature, frequency, and possible relation to patient age and underlying testicular pathology. Variations in histology included intranuclear eosinophilic inclusions, lipofuscin pigment, cribriform hyperplasia, Paneth cell-like metaplasia, and nuclear atypia. Intranuclear eosinophilic inclusions were observed in 72.5% of patients, and they appeared to occur at an older age than cribriform hyperplasia and Paneth cell-like metaplasia. Lipofuscin pigment was found in 32.9% of patients; this change was observed predominantly in ductuli efferentes and was more commonly associated with obstructive changes. Cribriform hyperplasia was seen in 41.9% of patients, and it occurred in 1 normal testis and in 33 testes with diverse pathologic alterations. Paneth cell-like metaplasia characterized by bright eosinophitic intracytoplasmic hyaline-like granules and globules, was present in 8.3% of patients and was accompanied by changes of obstruction in almost all instances. The globules were strongly periodic acid-Schiff positive, both before and after diastase digestion, and were negative for chromogranin A, KP-1, and MAC387 immunostains. Nuclear atypia, similar to that seen in seminal vesicles, was focally present in 13.8% of patients and tended to occur at an older age. The authors conclude that variations in epididymal morphology are fairly common and, therefore, surgical pathologists should be aware of these changes. Although exuberant in some patients, in no cases did these variations cause serious diagnostic problems.

Original languageEnglish (US)
Pages (from-to)990-996
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume22
Issue number8
DOIs
StatePublished - Aug 1 1998
Externally publishedYes

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Orchiectomy
Epididymis
Paneth Cells
Metaplasia
Hyperplasia
Lipofuscin
Intranuclear Inclusion Bodies
Testis
Histology
Chromogranin A
Periodic Acid
Hyalin
Seminal Vesicles
Amylases
Digestion
Pathology

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Histologic variations in the epididymis : Findings in 167 orchiectomy specimens. / Shah, Varsha I.; Ro, Jae Y.; Amin, Mahul; Mullick, Seema; Nazeer, Tipu; Ayala, Alberto G.

In: American Journal of Surgical Pathology, Vol. 22, No. 8, 01.08.1998, p. 990-996.

Research output: Contribution to journalArticle

Shah, Varsha I. ; Ro, Jae Y. ; Amin, Mahul ; Mullick, Seema ; Nazeer, Tipu ; Ayala, Alberto G. / Histologic variations in the epididymis : Findings in 167 orchiectomy specimens. In: American Journal of Surgical Pathology. 1998 ; Vol. 22, No. 8. pp. 990-996.
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