Histomorphology of thrombus organization, neointima formation, and foreign body response in retrieved human aneurysms treated with hydrocoil devices

Monika Killer, Adam Arthur, John D. Barr, Bernd Richling, Gregory M. Cruise

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Biological processes, such as thrombus organization, endothelialization, and foreign body response, that occur following embolization of intracranial aneurysms are poorly understood. We examined 13 human aneurysms (retrieved at autopsy 1-74 days postembolization) treated with hybrid hydrogel-platinum coil devices and platinum coils. The specimens were embedded in methyl methacrylate and ground sections were surface stained. Using light microscopy, thrombus organization in the sac, endothelialization of the neck, and foreign body response to the embolic devices were determined. The area percentages of the sac occupied by embolic devices and unorganized thrombus were quantified using image analysis. Thrombus organization increased over time, but was incomplete up to 74 days posttreatment. Neointima formation had started at 5 days upon dense fibrin depositions and progressed to form a new vessel wall at 74 days. The foreign body response to the hydrogel was characterized by mononuclear macrophages, while platinum coils were surrounded by multinuclear foreign body giant cells. Histometric aneurysm occlusion ranged from 89 to 100% and embolic devices occupied 31-64% of the aneurysm sac. These findings showed that the hydrogel-based devices occupied a large percentage of the aneurysm sac, provided a framework for thrombus organization to occur, and elicited less severe foreign body response than platinum coils.

Original languageEnglish (US)
Pages (from-to)486-492
Number of pages7
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume94
Issue number2
DOIs
StatePublished - Aug 1 2010

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Neointima
Foreign Bodies
Platinum
Aneurysm
Hydrogel
Thrombosis
Hydrogels
Organizations
Equipment and Supplies
Methacrylates
Foreign Body Giant Cells
Macrophages
Biological Phenomena
Fibrin
Image analysis
Optical microscopy
Intracranial Aneurysm
Microscopy
Autopsy
Neck

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biomaterials
  • Medicine(all)

Cite this

Histomorphology of thrombus organization, neointima formation, and foreign body response in retrieved human aneurysms treated with hydrocoil devices. / Killer, Monika; Arthur, Adam; Barr, John D.; Richling, Bernd; Cruise, Gregory M.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 94, No. 2, 01.08.2010, p. 486-492.

Research output: Contribution to journalArticle

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