Historic perspectives and recent advances in major animal models of hypertension

Zhongjie Sun, Zhong E. Zhang

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Hypertension and related cardiovascular diseases are the leading causes of death in many countries. The etiology of human essential hypertension is largely unknown. It is highly likely that hypertension is a complex and multifactorial disease resulting from the interaction of multiple genetic and environmental factors. Animal models of hypertension have been proved to be useful to study the pathogenesis of, and to find a new therapy for, hypertension. The aim of this article is to briefly review the most widely used rodent models of experimental hypertension, including history and recent advances. These models are classified as genetically-induced, environmentally-induced, pharmacologically-induced, and renal-induced hypertension according to the way of induction; the typical representatives of each of these major types of experimental hypertension are spontaneous hypertension, cold-induced hypertension, DOCA-salt-induced hypertension, and renal-induced hypertension, respectively. The processes of induction of hypertension, possible pathogenesis, characteristics, advantages, and limitations of these animal models are reviewed. In addition, the clinical implications of the above experimental models of hypertension are addressed.

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalActa Pharmacologica Sinica
Volume26
Issue number3
DOIs
StatePublished - Mar 1 2005

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Animal Models
Hypertension
Renal Hypertension
Theoretical Models
Desoxycorticosterone Acetate
Cause of Death
Rodentia
Cardiovascular Diseases
Salts
History

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Historic perspectives and recent advances in major animal models of hypertension. / Sun, Zhongjie; Zhang, Zhong E.

In: Acta Pharmacologica Sinica, Vol. 26, No. 3, 01.03.2005, p. 295-301.

Research output: Contribution to journalReview article

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