Homophila

Human disease gene cognates in Drosophila

Samson Chien, Lawrence Reiter, Ethan Bier, Michael Gribskov

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Although many human genes have been associated with genetic diseases, knowing which mutations result in disease phenotypes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate human genetic diseases. Homophila is an intergenomic resource linking the human and fly genomes in order to stimulate functional genomic investigations in Drosophila that address questions about genetic disease in humans. Homophila provides a comprehensive linkage between the disease genes compiled in Online Mendelian Inheritance in Man (OMIM) and the complete Drosophila genomic sequence. Homophila is a relational database that allows searching based on human disease descriptions, OMIM number, human or fly gene names, and sequence similarity, and can be accessed at http://homophila.sdsc.edu.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
JournalNucleic Acids Research
Volume30
Issue number1
StatePublished - Jan 1 2002
Externally publishedYes

Fingerprint

Inborn Genetic Diseases
Drosophila
Genetic Databases
Diptera
Genes
Medical Genetics
Human Genome
Drosophila melanogaster
Names
Molecular Biology
Databases
Phenotype
Mutation

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Chien, S., Reiter, L., Bier, E., & Gribskov, M. (2002). Homophila: Human disease gene cognates in Drosophila. Nucleic Acids Research, 30(1), 149-151.

Homophila : Human disease gene cognates in Drosophila. / Chien, Samson; Reiter, Lawrence; Bier, Ethan; Gribskov, Michael.

In: Nucleic Acids Research, Vol. 30, No. 1, 01.01.2002, p. 149-151.

Research output: Contribution to journalArticle

Chien, S, Reiter, L, Bier, E & Gribskov, M 2002, 'Homophila: Human disease gene cognates in Drosophila', Nucleic Acids Research, vol. 30, no. 1, pp. 149-151.
Chien S, Reiter L, Bier E, Gribskov M. Homophila: Human disease gene cognates in Drosophila. Nucleic Acids Research. 2002 Jan 1;30(1):149-151.
Chien, Samson ; Reiter, Lawrence ; Bier, Ethan ; Gribskov, Michael. / Homophila : Human disease gene cognates in Drosophila. In: Nucleic Acids Research. 2002 ; Vol. 30, No. 1. pp. 149-151.
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