Hormone response units

One plus one equals more than two

William J. Roesler, Edwards Park

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The transcription rate of many genes, and particularly those which code for metabolically important proteins, is regulated by various hormones. Detailed analysis of the promoters of these genes has shown that, while functional 'Hormone response elements' exist, the hormonal responsiveness of many promoters is often synergistically mediated by several cis-elements, collectively referred to as a hormone response unit. The utilization of a hormone response unit to mediate a response offers several regulatory advantages, including an expansion of the range of transcriptional responses and modulation of the response by tissue- and developmental-specific cues. Furthermore, the presence of Hormone Response Units may provide a mechanism for the coordination of information from two or more signaling pathways into a single, integrated and exquisitely controlled transcriptional response. The protein-protein interactions that likely mediate many of the synergistic functional characteristics of Hormone Response Units may provide unique targets for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalMolecular and Cellular Biochemistry
Volume178
Issue number1-2
DOIs
StatePublished - Mar 31 1998

Fingerprint

Hormones
Genes
Proteins
Response Elements
Transcription
Cues
Modulation
Tissue
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Hormone response units : One plus one equals more than two. / Roesler, William J.; Park, Edwards.

In: Molecular and Cellular Biochemistry, Vol. 178, No. 1-2, 31.03.1998, p. 1-8.

Research output: Contribution to journalReview article

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