Hospitalization and change in body composition and strength in a population-based cohort of older persons

Dawn E. Alley, Annemarie Koster, Dawn MacKey, Peggy Cawthon, Luigi Ferrucci, Eleanor M. Simonsick, Binbing Yu, Susan Hardy, Bret Goodpaster, Catherine Sarkisian, Denise K. Houston, Stephen B. Kritchevsky, Steven Cummings, Jung Sun Lee, Frances Tylavsky, Anne Newman, Tamara Harris

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

OBJECTIVES: To examine the association between hospitalization and annual changes in body composition and strength in older adults. DESIGN: Cohort study. SETTING: Clinic examinations in Pittsburgh, Pennsylvania, or Memphis, Tennessee. PARTICIPANTS: Well-functioning adults aged 70 to 79 who participated in the Health, Aging and Body Composition Study. MEASUREMENTS: Hospitalizations were reported at annual clinic visits and in semiannual phone interviews. In the event of death or reported hospitalization, hospitalizations were adjudicated according to medical record review. Dual X-ray absorptiometry (DXA) assessments of total, lean, and fat mass were conducted in six annual examinations, and measures of knee extensor strength were conducted in two annual examinations. RESULTS: DXA assessments followed 2,309 hospitalizations. In men and women, hospitalization in the previous year was associated with greater declines in total mass (-0.76 and-0.81 kg, respectively), fat mass (-0.41 and-0.54 kg), and lean mass (-0.33 and-0.25 kg) (P<.001 for all) than in nonhospitalized participants, after adjustment for demographics and baseline values. Hospitalization was associated with strength declines in men (-4.02 Nm, P=.046) but not in women. Relationships were similar after adjusting for health behaviors and chronic conditions, although the association between hospitalization and strength was attenuated. Associations increased with number of days hospitalized; hospitalizations totaling 8 days or more in the previous year were associated with significantly greater loss of total, lean, and fat mass and loss of strength in both sexes than in nonhospitalized participants. CONCLUSION: Hospitalization is associated with significant changes in body composition and strength in older persons. These effects appear particularly important in persons hospitalized for 8 or more days per year.

Original languageEnglish (US)
Pages (from-to)2085-2091
Number of pages7
JournalJournal of the American Geriatrics Society
Volume58
Issue number11
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

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Body Composition
Hospitalization
Population
Fats
Photon Absorptiometry
Health Behavior
Ambulatory Care
Medical Records
Knee
Cohort Studies
Demography
Interviews
Health

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Hospitalization and change in body composition and strength in a population-based cohort of older persons. / Alley, Dawn E.; Koster, Annemarie; MacKey, Dawn; Cawthon, Peggy; Ferrucci, Luigi; Simonsick, Eleanor M.; Yu, Binbing; Hardy, Susan; Goodpaster, Bret; Sarkisian, Catherine; Houston, Denise K.; Kritchevsky, Stephen B.; Cummings, Steven; Lee, Jung Sun; Tylavsky, Frances; Newman, Anne; Harris, Tamara.

In: Journal of the American Geriatrics Society, Vol. 58, No. 11, 01.11.2010, p. 2085-2091.

Research output: Contribution to journalArticle

Alley, DE, Koster, A, MacKey, D, Cawthon, P, Ferrucci, L, Simonsick, EM, Yu, B, Hardy, S, Goodpaster, B, Sarkisian, C, Houston, DK, Kritchevsky, SB, Cummings, S, Lee, JS, Tylavsky, F, Newman, A & Harris, T 2010, 'Hospitalization and change in body composition and strength in a population-based cohort of older persons', Journal of the American Geriatrics Society, vol. 58, no. 11, pp. 2085-2091. https://doi.org/10.1111/j.1532-5415.2010.03144.x
Alley, Dawn E. ; Koster, Annemarie ; MacKey, Dawn ; Cawthon, Peggy ; Ferrucci, Luigi ; Simonsick, Eleanor M. ; Yu, Binbing ; Hardy, Susan ; Goodpaster, Bret ; Sarkisian, Catherine ; Houston, Denise K. ; Kritchevsky, Stephen B. ; Cummings, Steven ; Lee, Jung Sun ; Tylavsky, Frances ; Newman, Anne ; Harris, Tamara. / Hospitalization and change in body composition and strength in a population-based cohort of older persons. In: Journal of the American Geriatrics Society. 2010 ; Vol. 58, No. 11. pp. 2085-2091.
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T1 - Hospitalization and change in body composition and strength in a population-based cohort of older persons

AU - Alley, Dawn E.

AU - Koster, Annemarie

AU - MacKey, Dawn

AU - Cawthon, Peggy

AU - Ferrucci, Luigi

AU - Simonsick, Eleanor M.

AU - Yu, Binbing

AU - Hardy, Susan

AU - Goodpaster, Bret

AU - Sarkisian, Catherine

AU - Houston, Denise K.

AU - Kritchevsky, Stephen B.

AU - Cummings, Steven

AU - Lee, Jung Sun

AU - Tylavsky, Frances

AU - Newman, Anne

AU - Harris, Tamara

PY - 2010/11/1

Y1 - 2010/11/1

N2 - OBJECTIVES: To examine the association between hospitalization and annual changes in body composition and strength in older adults. DESIGN: Cohort study. SETTING: Clinic examinations in Pittsburgh, Pennsylvania, or Memphis, Tennessee. PARTICIPANTS: Well-functioning adults aged 70 to 79 who participated in the Health, Aging and Body Composition Study. MEASUREMENTS: Hospitalizations were reported at annual clinic visits and in semiannual phone interviews. In the event of death or reported hospitalization, hospitalizations were adjudicated according to medical record review. Dual X-ray absorptiometry (DXA) assessments of total, lean, and fat mass were conducted in six annual examinations, and measures of knee extensor strength were conducted in two annual examinations. RESULTS: DXA assessments followed 2,309 hospitalizations. In men and women, hospitalization in the previous year was associated with greater declines in total mass (-0.76 and-0.81 kg, respectively), fat mass (-0.41 and-0.54 kg), and lean mass (-0.33 and-0.25 kg) (P<.001 for all) than in nonhospitalized participants, after adjustment for demographics and baseline values. Hospitalization was associated with strength declines in men (-4.02 Nm, P=.046) but not in women. Relationships were similar after adjusting for health behaviors and chronic conditions, although the association between hospitalization and strength was attenuated. Associations increased with number of days hospitalized; hospitalizations totaling 8 days or more in the previous year were associated with significantly greater loss of total, lean, and fat mass and loss of strength in both sexes than in nonhospitalized participants. CONCLUSION: Hospitalization is associated with significant changes in body composition and strength in older persons. These effects appear particularly important in persons hospitalized for 8 or more days per year.

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