Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort

Beth A. Kurt, Vikki G. Nolan, Kirsten K. Ness, Joseph P. Neglia, Jean M. Tersak, Melissa M. Hudson, Gregory Armstrong, Raymond J. Hutchinson, Wendy M. Leisenring, Kevin C. Oeffinger, Leslie L. Robison, Mukta Arora

Research output: Contribution to journalArticle

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Abstract

Background: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. Procedure: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated. Results: Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR=2.6, 95% CI: 2.2; 3.0) and female (SIR=2.7, 95% CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization. Conclusions: Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalPediatric Blood and Cancer
Volume59
Issue number1
DOIs
StatePublished - Jul 15 2012
Externally publishedYes

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Survivors
Hospitalization
Cohort Studies
Neoplasms
Second Primary Neoplasms
Incidence
Population
Health
Economics
Demography
Radiation
Delivery of Health Care
Therapeutics
Research

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)
  • Hematology
  • Oncology

Cite this

Kurt, B. A., Nolan, V. G., Ness, K. K., Neglia, J. P., Tersak, J. M., Hudson, M. M., ... Arora, M. (2012). Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort. Pediatric Blood and Cancer, 59(1), 126-132. https://doi.org/10.1002/pbc.24017

Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort. / Kurt, Beth A.; Nolan, Vikki G.; Ness, Kirsten K.; Neglia, Joseph P.; Tersak, Jean M.; Hudson, Melissa M.; Armstrong, Gregory; Hutchinson, Raymond J.; Leisenring, Wendy M.; Oeffinger, Kevin C.; Robison, Leslie L.; Arora, Mukta.

In: Pediatric Blood and Cancer, Vol. 59, No. 1, 15.07.2012, p. 126-132.

Research output: Contribution to journalArticle

Kurt, BA, Nolan, VG, Ness, KK, Neglia, JP, Tersak, JM, Hudson, MM, Armstrong, G, Hutchinson, RJ, Leisenring, WM, Oeffinger, KC, Robison, LL & Arora, M 2012, 'Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort', Pediatric Blood and Cancer, vol. 59, no. 1, pp. 126-132. https://doi.org/10.1002/pbc.24017
Kurt, Beth A. ; Nolan, Vikki G. ; Ness, Kirsten K. ; Neglia, Joseph P. ; Tersak, Jean M. ; Hudson, Melissa M. ; Armstrong, Gregory ; Hutchinson, Raymond J. ; Leisenring, Wendy M. ; Oeffinger, Kevin C. ; Robison, Leslie L. ; Arora, Mukta. / Hospitalization rates among survivors of childhood cancer in the childhood cancer survivor study cohort. In: Pediatric Blood and Cancer. 2012 ; Vol. 59, No. 1. pp. 126-132.
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abstract = "Background: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. Procedure: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated. Results: Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95{\%} CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR=2.6, 95{\%} CI: 2.2; 3.0) and female (SIR=2.7, 95{\%} CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization. Conclusions: Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages.",
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AU - Kurt, Beth A.

AU - Nolan, Vikki G.

AU - Ness, Kirsten K.

AU - Neglia, Joseph P.

AU - Tersak, Jean M.

AU - Hudson, Melissa M.

AU - Armstrong, Gregory

AU - Hutchinson, Raymond J.

AU - Leisenring, Wendy M.

AU - Oeffinger, Kevin C.

AU - Robison, Leslie L.

AU - Arora, Mukta

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N2 - Background: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. Procedure: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated. Results: Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR=2.6, 95% CI: 2.2; 3.0) and female (SIR=2.7, 95% CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization. Conclusions: Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages.

AB - Background: Chronic health conditions are common among long-term childhood cancer survivors, but hospitalization rates have not been reported. The objective of this study was to determine overall and cause-specific hospitalization rates among survivors of childhood cancer and compare rates to the U.S. population. Procedure: The Childhood Cancer Survivor Study (CCSS) is a retrospective cohort of 5+ year survivors of childhood malignancies treated at 26 participating centers. Self-reported hospitalizations from 10,366 survivors (diagnosed 1970-1986) were compared to U.S. population rates using age- and sex-stratified standardized incidence ratios (SIRs). Reasons for hospitalization were evaluated and associations between demographic, cancer and treatment-related risk factors with hospitalization were investigated. Results: Survivors were, on average, 20.9 years from cancer diagnosis (SD: 4.6, range: 13-32) and 28.6 years of age (SD: 7.7, range: 13-51). Survivor hospitalization rates were 1.6 times the U.S. population (95% CI: 1.6; 1.7). Increased hospitalization rates were noted irrespective of gender, age at follow-up and cancer diagnosis, with highest SIRs noted among male (SIR=2.6, 95% CI: 2.2; 3.0) and female (SIR=2.7, 95% CI: 2.4; 3.1) survivors aged 45-54. Female gender, an existing chronic health condition and/or a second neoplasm, and prior treatment with radiation were associated with an increased risk of non-obstetrical hospitalization. Conclusions: Survivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment-related complications as this population ages.

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