HTLV-1 induced molecular mimicry in neurological disease

Sang Lee, Y. Morcos, H. Jang, J. M. Stuart, M. C. Levin

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

As a model for molecular mimicry, we study patients infected with human T-lymphotropic virus type 1 (HTLV-1) who develop a neurological disease called HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a disease with important biological similarities to multiple sclerosis (MS) (Khan et al. 2001; Levin et al. 1998, 2002a; Levin and Jacobson 1997). The study of HAM/TSP, a disease associated with a known environmental agent (HTLV-1), allows for the direct comparison of the infecting agent with host antigens. Neurological disease in HAM/TSP patients is associated with immune responses to HTLV-1-tax (a regulatory and immunodominant protein) and human histocompatibility leukocyte antigen (HLA) DRB1*0101 (Bangham 2000; Jacobson et al. 1990; Jeffery et al. 1999; Lal 1996). Recently, we showed that HAM/TSP patients make antibodies to heterogeneous nuclear ribonuclear protein Al (hnRNP Al), a neuron-specific autoantigen (Levin et al. 2002a). Monoclonal antibodies to tax cross-reacted with hnRNP Al, indicating molecular mimicry between the two proteins. Infusion of cross-reactive antibodies with an ex vivo system completely inhibited neuronal firing indicative of their pathogenic nature (Kalume et al. 2004; Levin et al. 2002a). These data demonstrate a clear link between chronic viral infection and autoimmune disease of the central nervous system (CNS) in humans and, we believe, in turn will give insight into the pathogenesis of MS.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalCurrent Topics in Microbiology and Immunology
Volume296
StatePublished - Nov 30 2005

Fingerprint

Molecular Mimicry
Human T-lymphotropic virus 1
Tropical Spastic Paraparesis
Spinal Cord Diseases
Virus Diseases
Nuclear Proteins
Multiple Sclerosis
Autoimmune Diseases of the Nervous System
Histocompatibility Antigens
Antibodies
Autoantigens
HLA Antigens
Proteins
Central Nervous System
Monoclonal Antibodies
Neurons
Antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Lee, S., Morcos, Y., Jang, H., Stuart, J. M., & Levin, M. C. (2005). HTLV-1 induced molecular mimicry in neurological disease. Current Topics in Microbiology and Immunology, 296, 125-136.

HTLV-1 induced molecular mimicry in neurological disease. / Lee, Sang; Morcos, Y.; Jang, H.; Stuart, J. M.; Levin, M. C.

In: Current Topics in Microbiology and Immunology, Vol. 296, 30.11.2005, p. 125-136.

Research output: Contribution to journalReview article

Lee, S, Morcos, Y, Jang, H, Stuart, JM & Levin, MC 2005, 'HTLV-1 induced molecular mimicry in neurological disease', Current Topics in Microbiology and Immunology, vol. 296, pp. 125-136.
Lee, Sang ; Morcos, Y. ; Jang, H. ; Stuart, J. M. ; Levin, M. C. / HTLV-1 induced molecular mimicry in neurological disease. In: Current Topics in Microbiology and Immunology. 2005 ; Vol. 296. pp. 125-136.
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