HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a Cohort of Caucasians and African Americans

An evaluation of gene-environment interactions and candidate genes

Todd L. Edwards, Digna R. Velez Edwards, Raquel Villegas, Sarah S. Cohen, MacIej S. Buchowski, Jay Fowke, David Schlundt, Ji Rong Long, Qiuyin Cai, Wei Zheng, Xiao Ou Shu, Margaret K. Hargreaves, Smith Jeffrey, Scott M. Williams, Lisa B. Signorello, William J. Blot, Charles E. Matthews

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The World Health Organization estimates that the number of obese and overweight adults has increased to 1.6 billion, with concomitant increases in comorbidity. While genetic factors for obesity have been extensively studied in Caucasians, fewer studies have investigated genetic determinants of body mass index (BMI; weight (kg)/height (m) 2) in African Americans. A total of 38 genes and 1,086 single nucleotide polymorphisms (SNPs) in African Americans (n = 1,173) and 897 SNPs in Caucasians (n = 1,165) were examined in the Southern Community Cohort Study (2002-2009) for associations with BMI and gene × environment interactions. A statistically significant association with BMI survived correction for multiple testing at rs4140535 (β =-0.04, 95% confidence interval:-0.06,-0.02; P = 5.76 × 10 -5) in African Americans but not in Caucasians. Gene-environment interactions were observed with cigarette smoking and a SNP in ADIPOR1 in African Americans, as well as between a different SNP in ADIPOR1 and physical activity in Caucasians. A SNP in PPARGC1A interacted with alcohol consumption in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians. A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians.

Original languageEnglish (US)
Pages (from-to)11-21
Number of pages11
JournalAmerican Journal of Epidemiology
Volume175
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Gene-Environment Interaction
African Americans
Single Nucleotide Polymorphism
Obesity
Genes
Energy Intake
Alcohol Drinking
Comorbidity
Body Mass Index
Cohort Studies
Smoking
Confidence Intervals
Exercise
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a Cohort of Caucasians and African Americans : An evaluation of gene-environment interactions and candidate genes. / Edwards, Todd L.; Velez Edwards, Digna R.; Villegas, Raquel; Cohen, Sarah S.; Buchowski, MacIej S.; Fowke, Jay; Schlundt, David; Long, Ji Rong; Cai, Qiuyin; Zheng, Wei; Shu, Xiao Ou; Hargreaves, Margaret K.; Jeffrey, Smith; Williams, Scott M.; Signorello, Lisa B.; Blot, William J.; Matthews, Charles E.

In: American Journal of Epidemiology, Vol. 175, No. 1, 01.01.2012, p. 11-21.

Research output: Contribution to journalArticle

Edwards, TL, Velez Edwards, DR, Villegas, R, Cohen, SS, Buchowski, MS, Fowke, J, Schlundt, D, Long, JR, Cai, Q, Zheng, W, Shu, XO, Hargreaves, MK, Jeffrey, S, Williams, SM, Signorello, LB, Blot, WJ & Matthews, CE 2012, 'HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a Cohort of Caucasians and African Americans: An evaluation of gene-environment interactions and candidate genes', American Journal of Epidemiology, vol. 175, no. 1, pp. 11-21. https://doi.org/10.1093/aje/kwr272
Edwards, Todd L. ; Velez Edwards, Digna R. ; Villegas, Raquel ; Cohen, Sarah S. ; Buchowski, MacIej S. ; Fowke, Jay ; Schlundt, David ; Long, Ji Rong ; Cai, Qiuyin ; Zheng, Wei ; Shu, Xiao Ou ; Hargreaves, Margaret K. ; Jeffrey, Smith ; Williams, Scott M. ; Signorello, Lisa B. ; Blot, William J. ; Matthews, Charles E. / HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a Cohort of Caucasians and African Americans : An evaluation of gene-environment interactions and candidate genes. In: American Journal of Epidemiology. 2012 ; Vol. 175, No. 1. pp. 11-21.
@article{8328ac9ab2ef4b09b7ec7f2273dbd3ea,
title = "HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a Cohort of Caucasians and African Americans: An evaluation of gene-environment interactions and candidate genes",
abstract = "The World Health Organization estimates that the number of obese and overweight adults has increased to 1.6 billion, with concomitant increases in comorbidity. While genetic factors for obesity have been extensively studied in Caucasians, fewer studies have investigated genetic determinants of body mass index (BMI; weight (kg)/height (m) 2) in African Americans. A total of 38 genes and 1,086 single nucleotide polymorphisms (SNPs) in African Americans (n = 1,173) and 897 SNPs in Caucasians (n = 1,165) were examined in the Southern Community Cohort Study (2002-2009) for associations with BMI and gene × environment interactions. A statistically significant association with BMI survived correction for multiple testing at rs4140535 (β =-0.04, 95{\%} confidence interval:-0.06,-0.02; P = 5.76 × 10 -5) in African Americans but not in Caucasians. Gene-environment interactions were observed with cigarette smoking and a SNP in ADIPOR1 in African Americans, as well as between a different SNP in ADIPOR1 and physical activity in Caucasians. A SNP in PPARGC1A interacted with alcohol consumption in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians. A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians.",
author = "Edwards, {Todd L.} and {Velez Edwards}, {Digna R.} and Raquel Villegas and Cohen, {Sarah S.} and Buchowski, {MacIej S.} and Jay Fowke and David Schlundt and Long, {Ji Rong} and Qiuyin Cai and Wei Zheng and Shu, {Xiao Ou} and Hargreaves, {Margaret K.} and Smith Jeffrey and Williams, {Scott M.} and Signorello, {Lisa B.} and Blot, {William J.} and Matthews, {Charles E.}",
year = "2012",
month = "1",
day = "1",
doi = "10.1093/aje/kwr272",
language = "English (US)",
volume = "175",
pages = "11--21",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a Cohort of Caucasians and African Americans

T2 - An evaluation of gene-environment interactions and candidate genes

AU - Edwards, Todd L.

AU - Velez Edwards, Digna R.

AU - Villegas, Raquel

AU - Cohen, Sarah S.

AU - Buchowski, MacIej S.

AU - Fowke, Jay

AU - Schlundt, David

AU - Long, Ji Rong

AU - Cai, Qiuyin

AU - Zheng, Wei

AU - Shu, Xiao Ou

AU - Hargreaves, Margaret K.

AU - Jeffrey, Smith

AU - Williams, Scott M.

AU - Signorello, Lisa B.

AU - Blot, William J.

AU - Matthews, Charles E.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - The World Health Organization estimates that the number of obese and overweight adults has increased to 1.6 billion, with concomitant increases in comorbidity. While genetic factors for obesity have been extensively studied in Caucasians, fewer studies have investigated genetic determinants of body mass index (BMI; weight (kg)/height (m) 2) in African Americans. A total of 38 genes and 1,086 single nucleotide polymorphisms (SNPs) in African Americans (n = 1,173) and 897 SNPs in Caucasians (n = 1,165) were examined in the Southern Community Cohort Study (2002-2009) for associations with BMI and gene × environment interactions. A statistically significant association with BMI survived correction for multiple testing at rs4140535 (β =-0.04, 95% confidence interval:-0.06,-0.02; P = 5.76 × 10 -5) in African Americans but not in Caucasians. Gene-environment interactions were observed with cigarette smoking and a SNP in ADIPOR1 in African Americans, as well as between a different SNP in ADIPOR1 and physical activity in Caucasians. A SNP in PPARGC1A interacted with alcohol consumption in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians. A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians.

AB - The World Health Organization estimates that the number of obese and overweight adults has increased to 1.6 billion, with concomitant increases in comorbidity. While genetic factors for obesity have been extensively studied in Caucasians, fewer studies have investigated genetic determinants of body mass index (BMI; weight (kg)/height (m) 2) in African Americans. A total of 38 genes and 1,086 single nucleotide polymorphisms (SNPs) in African Americans (n = 1,173) and 897 SNPs in Caucasians (n = 1,165) were examined in the Southern Community Cohort Study (2002-2009) for associations with BMI and gene × environment interactions. A statistically significant association with BMI survived correction for multiple testing at rs4140535 (β =-0.04, 95% confidence interval:-0.06,-0.02; P = 5.76 × 10 -5) in African Americans but not in Caucasians. Gene-environment interactions were observed with cigarette smoking and a SNP in ADIPOR1 in African Americans, as well as between a different SNP in ADIPOR1 and physical activity in Caucasians. A SNP in PPARGC1A interacted with alcohol consumption in African Americans, and a different SNP in PPARGC1A was nominally associated in Caucasians. A SNP in CYP19A1 interacted with dietary energy intake in African Americans, and another SNP in CYP191A had an independent association with BMI in Caucasians.

UR - http://www.scopus.com/inward/record.url?scp=84555170656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84555170656&partnerID=8YFLogxK

U2 - 10.1093/aje/kwr272

DO - 10.1093/aje/kwr272

M3 - Article

VL - 175

SP - 11

EP - 21

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 1

ER -