Human λ light-chain constant region gene C(λ)(Mor)

The primary structure of λVI Bence Jones protein Mor

B. Frangione, T. Moloshok, F. Prelli, Alan Solomon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Serologic, structural, and genetic analyses have shown that the constant (C) region of human κ light chains is encoded by a single gene, whereas that of λ chains is encoded by multiple genes. We have determined the complete C region amino acid sequence of two monoclonal λVI light chains, Bence Jones proteins Sut and Mor. The C region of λ chains Sut and Mor consists of 105 residues, as is characteristic for human λ light chains, of which 102 are identical in sequence. Protein Sut has the C region sequence associated with the C(λ) isotype Mcg-, Kern-, Oz+ and represents a product of the C(λ)3 (Kern-, Oz+) gene. Protein Mor has a C region sequence associated with Mcg-, Kern-, and Oz- proteins but differs from protein Sut by the presence of three amino acid interchanges at positions 168, 176, and 194. These substitutions distinguish protein Mor from λ chains encoded by the C(λ)1 (Mcg+), C(λ)2 (Kern-, Oz-), and C(λ)3 (Kern-, Oz+) genes and provide further evidence for polymorphism of the human C(λ) genome. The gene encoding the C region sequence of λ chain Mor is designated C(λ)(Mor).

Original languageEnglish (US)
Pages (from-to)3415-3419
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number10
DOIs
StatePublished - Jan 1 1985

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Bence Jones Protein
Light
Genes
Proteins
Human Genome
Amino Acid Sequence
Amino Acids

All Science Journal Classification (ASJC) codes

  • General

Cite this

Human λ light-chain constant region gene C(λ)(Mor) : The primary structure of λVI Bence Jones protein Mor. / Frangione, B.; Moloshok, T.; Prelli, F.; Solomon, Alan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, No. 10, 01.01.1985, p. 3415-3419.

Research output: Contribution to journalArticle

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AU - Solomon, Alan

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N2 - Serologic, structural, and genetic analyses have shown that the constant (C) region of human κ light chains is encoded by a single gene, whereas that of λ chains is encoded by multiple genes. We have determined the complete C region amino acid sequence of two monoclonal λVI light chains, Bence Jones proteins Sut and Mor. The C region of λ chains Sut and Mor consists of 105 residues, as is characteristic for human λ light chains, of which 102 are identical in sequence. Protein Sut has the C region sequence associated with the C(λ) isotype Mcg-, Kern-, Oz+ and represents a product of the C(λ)3 (Kern-, Oz+) gene. Protein Mor has a C region sequence associated with Mcg-, Kern-, and Oz- proteins but differs from protein Sut by the presence of three amino acid interchanges at positions 168, 176, and 194. These substitutions distinguish protein Mor from λ chains encoded by the C(λ)1 (Mcg+), C(λ)2 (Kern-, Oz-), and C(λ)3 (Kern-, Oz+) genes and provide further evidence for polymorphism of the human C(λ) genome. The gene encoding the C region sequence of λ chain Mor is designated C(λ)(Mor).

AB - Serologic, structural, and genetic analyses have shown that the constant (C) region of human κ light chains is encoded by a single gene, whereas that of λ chains is encoded by multiple genes. We have determined the complete C region amino acid sequence of two monoclonal λVI light chains, Bence Jones proteins Sut and Mor. The C region of λ chains Sut and Mor consists of 105 residues, as is characteristic for human λ light chains, of which 102 are identical in sequence. Protein Sut has the C region sequence associated with the C(λ) isotype Mcg-, Kern-, Oz+ and represents a product of the C(λ)3 (Kern-, Oz+) gene. Protein Mor has a C region sequence associated with Mcg-, Kern-, and Oz- proteins but differs from protein Sut by the presence of three amino acid interchanges at positions 168, 176, and 194. These substitutions distinguish protein Mor from λ chains encoded by the C(λ)1 (Mcg+), C(λ)2 (Kern-, Oz-), and C(λ)3 (Kern-, Oz+) genes and provide further evidence for polymorphism of the human C(λ) genome. The gene encoding the C region sequence of λ chain Mor is designated C(λ)(Mor).

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