Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region

Edward G. Stopa, Joan C. King, Ralph Lydic, William C. Schoene

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The suprachiasmatic nuclei (SCN) and retinohypothalamic tract (RHT) in the anterior hypothalamus have been postulated to play an important role in the timing of daily biological rhythms in mammals. Although physiological studies have described circadian rhythms in man, the presence of an RHT or SCN has not been conclusively demonstrated in the human brain. Immunocytochemical identification of distinct ventral vasoactive intestinal polypeptide (VIP) containing and dorsal vasopressin containing neuronal subpopulations in the human suprachiasmatic region provides correlative evidence of neuronal clusters which are homologous to discrete cell groups in the SCN of other mammalian species. Manipulation of the circadian system has been used to treat some affective illnesses and othe physiological timing disorders. Characterization of the neural substrates underlying human circadian rhythms could be useful in the development of future treatment modalities and is essential for understanding normal human circadian organization.

Original languageEnglish (US)
Pages (from-to)159-163
Number of pages5
JournalBrain Research
Volume297
Issue number1
DOIs
StatePublished - Apr 9 1984
Externally publishedYes

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Vasoactive Intestinal Peptide
Vasopressins
Suprachiasmatic Nucleus
Brain
Circadian Rhythm
Anterior Hypothalamus
Periodicity
Mammals
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Developmental Biology
  • Clinical Neurology

Cite this

Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region. / Stopa, Edward G.; King, Joan C.; Lydic, Ralph; Schoene, William C.

In: Brain Research, Vol. 297, No. 1, 09.04.1984, p. 159-163.

Research output: Contribution to journalArticle

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