Human herpesvirus 6 is associated with focal encephalitis

Jonathan Mccullers, Fred D. Lakeman, Richard J. Whitley

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Human herpesvirus 6 (HHV-6) is a cause of roseola infantum. Recent reports associate HHV-6 with cases of encephalitis; however, conclusive etiologic data do not exist. We evaluated clinical data and laboratory specimens obtained from patients with focal encephalitis of unknown etiology. Cerebrospinal fluid (CSF) specimens were tested by polymerase chain reaction for the presence of HHV-6 DNA.Selected samples were analyzed by DNA sequencing. We detected HHV-6 DNA in the CSF of nine of 138 patients. DNA sequencing revealed that group B strains of HHV-6 were present in those specimens that were analyzed. No significant differences could be demonstrated in clinical presentation, laboratory findings, or neurodiagnostic imaging results between the nine patients with confirmed HHV-6 infection and the 129 patients without evidence of HHV-6 infection. Neurological outcome for the nine HHV-6-infected patients varied from complete recovery without neurological deficit to death. Further prospectivestudy is warranted.

Original languageEnglish (US)
Pages (from-to)571-576
Number of pages6
JournalClinical Infectious Diseases
Volume21
Issue number3
DOIs
StatePublished - Jan 1 1995

Fingerprint

Human Herpesvirus 6
Encephalitis
Herpesviridae Infections
DNA Sequence Analysis
Cerebrospinal Fluid
Exanthema Subitum
DNA
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Human herpesvirus 6 is associated with focal encephalitis. / Mccullers, Jonathan; Lakeman, Fred D.; Whitley, Richard J.

In: Clinical Infectious Diseases, Vol. 21, No. 3, 01.01.1995, p. 571-576.

Research output: Contribution to journalArticle

Mccullers, Jonathan ; Lakeman, Fred D. ; Whitley, Richard J. / Human herpesvirus 6 is associated with focal encephalitis. In: Clinical Infectious Diseases. 1995 ; Vol. 21, No. 3. pp. 571-576.
@article{1b1d3631d2524bdeba5beacf74f78fdc,
title = "Human herpesvirus 6 is associated with focal encephalitis",
abstract = "Human herpesvirus 6 (HHV-6) is a cause of roseola infantum. Recent reports associate HHV-6 with cases of encephalitis; however, conclusive etiologic data do not exist. We evaluated clinical data and laboratory specimens obtained from patients with focal encephalitis of unknown etiology. Cerebrospinal fluid (CSF) specimens were tested by polymerase chain reaction for the presence of HHV-6 DNA.Selected samples were analyzed by DNA sequencing. We detected HHV-6 DNA in the CSF of nine of 138 patients. DNA sequencing revealed that group B strains of HHV-6 were present in those specimens that were analyzed. No significant differences could be demonstrated in clinical presentation, laboratory findings, or neurodiagnostic imaging results between the nine patients with confirmed HHV-6 infection and the 129 patients without evidence of HHV-6 infection. Neurological outcome for the nine HHV-6-infected patients varied from complete recovery without neurological deficit to death. Further prospectivestudy is warranted.",
author = "Jonathan Mccullers and Lakeman, {Fred D.} and Whitley, {Richard J.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1093/clinids/21.3.571",
language = "English (US)",
volume = "21",
pages = "571--576",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Human herpesvirus 6 is associated with focal encephalitis

AU - Mccullers, Jonathan

AU - Lakeman, Fred D.

AU - Whitley, Richard J.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Human herpesvirus 6 (HHV-6) is a cause of roseola infantum. Recent reports associate HHV-6 with cases of encephalitis; however, conclusive etiologic data do not exist. We evaluated clinical data and laboratory specimens obtained from patients with focal encephalitis of unknown etiology. Cerebrospinal fluid (CSF) specimens were tested by polymerase chain reaction for the presence of HHV-6 DNA.Selected samples were analyzed by DNA sequencing. We detected HHV-6 DNA in the CSF of nine of 138 patients. DNA sequencing revealed that group B strains of HHV-6 were present in those specimens that were analyzed. No significant differences could be demonstrated in clinical presentation, laboratory findings, or neurodiagnostic imaging results between the nine patients with confirmed HHV-6 infection and the 129 patients without evidence of HHV-6 infection. Neurological outcome for the nine HHV-6-infected patients varied from complete recovery without neurological deficit to death. Further prospectivestudy is warranted.

AB - Human herpesvirus 6 (HHV-6) is a cause of roseola infantum. Recent reports associate HHV-6 with cases of encephalitis; however, conclusive etiologic data do not exist. We evaluated clinical data and laboratory specimens obtained from patients with focal encephalitis of unknown etiology. Cerebrospinal fluid (CSF) specimens were tested by polymerase chain reaction for the presence of HHV-6 DNA.Selected samples were analyzed by DNA sequencing. We detected HHV-6 DNA in the CSF of nine of 138 patients. DNA sequencing revealed that group B strains of HHV-6 were present in those specimens that were analyzed. No significant differences could be demonstrated in clinical presentation, laboratory findings, or neurodiagnostic imaging results between the nine patients with confirmed HHV-6 infection and the 129 patients without evidence of HHV-6 infection. Neurological outcome for the nine HHV-6-infected patients varied from complete recovery without neurological deficit to death. Further prospectivestudy is warranted.

UR - http://www.scopus.com/inward/record.url?scp=0029099423&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029099423&partnerID=8YFLogxK

U2 - 10.1093/clinids/21.3.571

DO - 10.1093/clinids/21.3.571

M3 - Article

VL - 21

SP - 571

EP - 576

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 3

ER -