Human Ontogeny of Drug Transporters

Review and Recommendations of the Pediatric Transporter Working Group

K. L.R. Brouwer, L. M. Aleksunes, B. Brandys, G. P. Giacoia, G. Knipp, V. Lukacova, Bernd Meibohm, Sk Nigam, M. M Rieder, Sn De Wildt

Research output: Contribution to journalReview article

63 Citations (Scopus)

Abstract

The critical importance of membrane € bound transporters in pharmacotherapy is widely recognized, but little is known about drug transporter activity in children. In this white paper, the Pediatric Transporter Working Group presents a systematic review of the ontogeny of clinically relevant membrane transporters (e.g., SLC, ABC superfamilies) in intestine, liver, and kidney. Different developmental patterns for individual transporters emerge, but much remains unknown. Recommendations to increase our understanding of membrane transporters in pediatric pharmacotherapy are presented.

Original languageEnglish (US)
Pages (from-to)266-287
Number of pages22
JournalClinical Pharmacology and Therapeutics
Volume98
Issue number3
DOIs
StatePublished - Sep 1 2015

Fingerprint

Membrane Transport Proteins
Pediatrics
Pharmaceutical Preparations
Drug Therapy
Intestines
Kidney
Liver

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Brouwer, K. L. R., Aleksunes, L. M., Brandys, B., Giacoia, G. P., Knipp, G., Lukacova, V., ... Wildt, S. D. (2015). Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group. Clinical Pharmacology and Therapeutics, 98(3), 266-287. https://doi.org/10.1002/cpt.176

Human Ontogeny of Drug Transporters : Review and Recommendations of the Pediatric Transporter Working Group. / Brouwer, K. L.R.; Aleksunes, L. M.; Brandys, B.; Giacoia, G. P.; Knipp, G.; Lukacova, V.; Meibohm, Bernd; Nigam, Sk; M Rieder, M.; Wildt, Sn De.

In: Clinical Pharmacology and Therapeutics, Vol. 98, No. 3, 01.09.2015, p. 266-287.

Research output: Contribution to journalReview article

Brouwer, KLR, Aleksunes, LM, Brandys, B, Giacoia, GP, Knipp, G, Lukacova, V, Meibohm, B, Nigam, S, M Rieder, M & Wildt, SD 2015, 'Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group', Clinical Pharmacology and Therapeutics, vol. 98, no. 3, pp. 266-287. https://doi.org/10.1002/cpt.176
Brouwer, K. L.R. ; Aleksunes, L. M. ; Brandys, B. ; Giacoia, G. P. ; Knipp, G. ; Lukacova, V. ; Meibohm, Bernd ; Nigam, Sk ; M Rieder, M. ; Wildt, Sn De. / Human Ontogeny of Drug Transporters : Review and Recommendations of the Pediatric Transporter Working Group. In: Clinical Pharmacology and Therapeutics. 2015 ; Vol. 98, No. 3. pp. 266-287.
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