Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies

Brian O'Nuallain, Luis Acero, Angela D. Williams, Helen P. McWilliams Koeppen, Alfred Weber, Hans P. Schwarz, Jonathan Wall, Deborah T. Weiss, Alan Solomon

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Two conformers of aggregated Aβ, i.e., fibrils and oligomers, have been deemed important in the pathogenesis of Alzheimer's disease. We now report that intravenous immune globulin (IVIG) derived from pools of human plasma contains IgGs that recognize conformational epitopes present on fibrils and oligomers, but not their soluble monomelic precursor. We have used affinity chromatography to isolate these antibodies and have shown that they cross-reacted with comparable nanomolar avidity with both types of Aβ aggregates; notably, binding was not inhibited by soluble Aβ monomers. Our studies provide further support for investigating the therapeutic use of IVIG in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)12254-12256
Number of pages3
JournalBiochemistry
Volume47
Issue number47
DOIs
StatePublished - Nov 25 2008

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Plasma (human)
Intravenous Immunoglobulins
Oligomers
Alzheimer Disease
Immunoglobulin G
Affinity chromatography
Antibodies
Therapeutic Uses
Affinity Chromatography
Epitopes
Monomers

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

O'Nuallain, B., Acero, L., Williams, A. D., McWilliams Koeppen, H. P., Weber, A., Schwarz, H. P., ... Solomon, A. (2008). Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies. Biochemistry, 47(47), 12254-12256. https://doi.org/10.1021/bi801767k

Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies. / O'Nuallain, Brian; Acero, Luis; Williams, Angela D.; McWilliams Koeppen, Helen P.; Weber, Alfred; Schwarz, Hans P.; Wall, Jonathan; Weiss, Deborah T.; Solomon, Alan.

In: Biochemistry, Vol. 47, No. 47, 25.11.2008, p. 12254-12256.

Research output: Contribution to journalArticle

O'Nuallain, B, Acero, L, Williams, AD, McWilliams Koeppen, HP, Weber, A, Schwarz, HP, Wall, J, Weiss, DT & Solomon, A 2008, 'Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies', Biochemistry, vol. 47, no. 47, pp. 12254-12256. https://doi.org/10.1021/bi801767k
O'Nuallain B, Acero L, Williams AD, McWilliams Koeppen HP, Weber A, Schwarz HP et al. Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies. Biochemistry. 2008 Nov 25;47(47):12254-12256. https://doi.org/10.1021/bi801767k
O'Nuallain, Brian ; Acero, Luis ; Williams, Angela D. ; McWilliams Koeppen, Helen P. ; Weber, Alfred ; Schwarz, Hans P. ; Wall, Jonathan ; Weiss, Deborah T. ; Solomon, Alan. / Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies. In: Biochemistry. 2008 ; Vol. 47, No. 47. pp. 12254-12256.
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