Hypercalcemia mediated by parathyroid hormone-related protein as an early manifestation of pancreatic adenocarcinoma metastasis

A case report

Mark Rasnake, Christopher Glanton, Deborah Ornstein, Michael Osswald, Mitchell Garrison

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Humoral hypercalcemia of malignancy (HHM) is a paraneoplastic syndrome rarely associated with pancreatic adenocarcinoma. Parathyroid hormone-related peptide (PTHrP) is the central mediator of this condition. In our patient, hypercalcemia associated with elevated PTHrP was the initial manifestation of metastatic pancreatic adenocarcinoma. Successful palliation of HHM with bisphosphonates and loop diuretics has been previously reported and was effective in our patient. We report the first case of pancreatic adenocarcinoma metastasis after successful resection to present with hypercalcemia.

Original languageEnglish (US)
Pages (from-to)416-417
Number of pages2
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume24
Issue number4
DOIs
StatePublished - Aug 20 2001
Externally publishedYes

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Parathyroid Hormone-Related Protein
Hypercalcemia
Adenocarcinoma
Neoplasm Metastasis
Sodium Potassium Chloride Symporter Inhibitors
Paraneoplastic Syndromes
Diphosphonates
Humoral Hypercalcemia Of Malignancy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Hypercalcemia mediated by parathyroid hormone-related protein as an early manifestation of pancreatic adenocarcinoma metastasis : A case report. / Rasnake, Mark; Glanton, Christopher; Ornstein, Deborah; Osswald, Michael; Garrison, Mitchell.

In: American Journal of Clinical Oncology: Cancer Clinical Trials, Vol. 24, No. 4, 20.08.2001, p. 416-417.

Research output: Contribution to journalArticle

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