Hyperleptinaemia of end-stage renal disease is corrected by renal transplantation

Michael Landt, Daniel C. Brennan, Curtis A. Parvin, Karen S. Flavin, Samuel Dagogo-Jack, Daniel W. Coyne

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background. Previous studies have reported that patients with end-stage renal disease (ESRD) have elevated plasma leptin concentrations, but the cause and significance of the elevations are unknown. We studied leptin concentrations in 29 adults undergoing renal transplantation, to determine if restoration of renal function reduced leptin concentrations in ESRD. Methods. Leptin concentrations were measured by radioimmunoassay in plasma specimens collected within 1 week before transplant, 6 days post-transplant, and 60 days post-transplant. Results. Mean plasma leptin concentrations were higher in both male and female ESRD patients compared with a control population of similar age and body mass index (BMI), but most of the disparity was due to a minority of patients with grossly elevated concentrations; the majority of ESRD patients had normal or near-normal leptin concentrations after accounting for their adiposity with BMI. Six days after successful renal transplantation, average plasma leptin concentrations decreased to control levels. The grossly elevated pretransplant concentrations in a minority of patients were greatly reduced in relation to BMI, and the reduction persisted to 60 days post-transplant. The decrease in creatinine with transplant did not correlate with the decrease in leptin. Conclusions. These results demonstrate that restoration of renal function in ESRD patients reduces hyperleptinaemia, which provides further evidence of a cause/effect relationship between impaired renal function and abnormal leptin metabolism.

Original languageEnglish (US)
Pages (from-to)2271-2275
Number of pages5
JournalNephrology Dialysis Transplantation
Volume13
Issue number9
DOIs
StatePublished - Sep 1 1998
Externally publishedYes

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Leptin
Kidney Transplantation
Chronic Kidney Failure
Transplants
Body Mass Index
Kidney
Adiposity
Radioimmunoassay
Creatinine

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Hyperleptinaemia of end-stage renal disease is corrected by renal transplantation. / Landt, Michael; Brennan, Daniel C.; Parvin, Curtis A.; Flavin, Karen S.; Dagogo-Jack, Samuel; Coyne, Daniel W.

In: Nephrology Dialysis Transplantation, Vol. 13, No. 9, 01.09.1998, p. 2271-2275.

Research output: Contribution to journalArticle

Landt, Michael ; Brennan, Daniel C. ; Parvin, Curtis A. ; Flavin, Karen S. ; Dagogo-Jack, Samuel ; Coyne, Daniel W. / Hyperleptinaemia of end-stage renal disease is corrected by renal transplantation. In: Nephrology Dialysis Transplantation. 1998 ; Vol. 13, No. 9. pp. 2271-2275.
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