Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene

Juliette Gray, Giles S.H. Yeo, James J. Cox, Jenny Morton, Anna Lynne R. Adlam, Julia M. Keogh, Jack A. Yanovski, Areeg El Gharbawy, Joan C. Han, Y. C.Loraine Tung, John R. Hodges, F. Lucy Raymond, Stephen O'Rahilly, I. Sadaf Farooqi

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

The neurotrophin brain-derived neurotrophic factor (BDNF) inhibits food intake, and rodent models of BDNF disruption all exhibit increased food intake and obesity, as well as hyperactivity. We report an 8-year-old girl with hyperphagia and severe obesity, impaired cognitive function, and hyperactivity who harbored a de novo chromosomal inversion, 46,XX,inv(11)(p13p15.3), a region encompassing the BDNF gene. We have identified the proximal inversion breakpoint that lies 850 kb telomeric of the 5′ end of the BDNF gene. The patient's genomic DNA was heterozygous for a common coding polymorphism in BDNF, but monoallelic expression was seen in peripheral lymphocytes. Serum concentration of BDNF protein was reduced compared with age- and BMI-matched subjects. Haploinsufficiency for BDNF was associated with increased ad libitum food intake, severe early-onset obesity, hyperactivity, and cognitive impairment. These findings provide direct evidence for the role of the neurotrophin BDNF in human energy homeostasis, as well as in cognitive function, memory, and behavior.

Original languageEnglish (US)
Pages (from-to)3366-3371
Number of pages6
JournalDiabetes
Volume55
Issue number12
DOIs
StatePublished - Dec 1 2006

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Hyperphagia
Morbid Obesity
Brain-Derived Neurotrophic Factor
Cognition
Nerve Growth Factors
Genes
Eating
Obesity
Haploinsufficiency
Rodentia
Homeostasis
Lymphocytes
DNA
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. / Gray, Juliette; Yeo, Giles S.H.; Cox, James J.; Morton, Jenny; Adlam, Anna Lynne R.; Keogh, Julia M.; Yanovski, Jack A.; El Gharbawy, Areeg; Han, Joan C.; Tung, Y. C.Loraine; Hodges, John R.; Raymond, F. Lucy; O'Rahilly, Stephen; Farooqi, I. Sadaf.

In: Diabetes, Vol. 55, No. 12, 01.12.2006, p. 3366-3371.

Research output: Contribution to journalArticle

Gray, J, Yeo, GSH, Cox, JJ, Morton, J, Adlam, ALR, Keogh, JM, Yanovski, JA, El Gharbawy, A, Han, JC, Tung, YCL, Hodges, JR, Raymond, FL, O'Rahilly, S & Farooqi, IS 2006, 'Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene', Diabetes, vol. 55, no. 12, pp. 3366-3371. https://doi.org/10.2337/db06-0550
Gray, Juliette ; Yeo, Giles S.H. ; Cox, James J. ; Morton, Jenny ; Adlam, Anna Lynne R. ; Keogh, Julia M. ; Yanovski, Jack A. ; El Gharbawy, Areeg ; Han, Joan C. ; Tung, Y. C.Loraine ; Hodges, John R. ; Raymond, F. Lucy ; O'Rahilly, Stephen ; Farooqi, I. Sadaf. / Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. In: Diabetes. 2006 ; Vol. 55, No. 12. pp. 3366-3371.
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