Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs

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Abstract

We examined effects of hyperthermia on cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) in anesthetized, newborn pigs (2-5 days old). CBF and CMRO2 were measured during normothermia (38°C) and during hyperthermia induced by body heating (42°C). During normothermia, total CBF was 32 ± 3 ml·min-1·100 g-1 (n = 9), and CMRO2 was 1.34 ± 0.08 ml O2·100 g-1·min-1 (n = 7). During hyperthermia, total CBF increased by 97 ± 23% and CMRO2 by 65 ± 24%. We also examined whether cerebral resistance vessels were responsive under these conditions. During hyperthermia, total CBF was 63 ± 6 ml·min-1·100 g-1, and CMRO2 was 2.13 ± 0.27 ml O2·100 g-1·min-1. During sustained hyperthermia, intravenous injection of 5 mg/kg of indomethacin decreased total CBF by 45 ± 7% (n = 9), and CMRO2 fell by 55 ± 10% (n = 5). We conclude that 1) hyperthermia increases CBF and CMRO2, and 2) the dilated cerebrovascular bed during hyperthermia still is responsive to a constrictor stimulus.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume255
Issue number2
StatePublished - 1988

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Cerebrovascular Circulation
Fever
Swine
Induced Hyperthermia
Intravenous Injections
Indomethacin
Heating
Oxygen

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

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title = "Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs",
abstract = "We examined effects of hyperthermia on cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) in anesthetized, newborn pigs (2-5 days old). CBF and CMRO2 were measured during normothermia (38°C) and during hyperthermia induced by body heating (42°C). During normothermia, total CBF was 32 ± 3 ml·min-1·100 g-1 (n = 9), and CMRO2 was 1.34 ± 0.08 ml O2·100 g-1·min-1 (n = 7). During hyperthermia, total CBF increased by 97 ± 23{\%} and CMRO2 by 65 ± 24{\%}. We also examined whether cerebral resistance vessels were responsive under these conditions. During hyperthermia, total CBF was 63 ± 6 ml·min-1·100 g-1, and CMRO2 was 2.13 ± 0.27 ml O2·100 g-1·min-1. During sustained hyperthermia, intravenous injection of 5 mg/kg of indomethacin decreased total CBF by 45 ± 7{\%} (n = 9), and CMRO2 fell by 55 ± 10{\%} (n = 5). We conclude that 1) hyperthermia increases CBF and CMRO2, and 2) the dilated cerebrovascular bed during hyperthermia still is responsive to a constrictor stimulus.",
author = "Busija, {D. W.} and Charles Leffler and Massroor Pourcyrous",
year = "1988",
language = "English (US)",
volume = "255",
journal = "American Journal of Physiology",
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TY - JOUR

T1 - Hyperthermia increases cerebral metabolic rate and blood flow in neonatal pigs

AU - Busija, D. W.

AU - Leffler, Charles

AU - Pourcyrous, Massroor

PY - 1988

Y1 - 1988

N2 - We examined effects of hyperthermia on cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) in anesthetized, newborn pigs (2-5 days old). CBF and CMRO2 were measured during normothermia (38°C) and during hyperthermia induced by body heating (42°C). During normothermia, total CBF was 32 ± 3 ml·min-1·100 g-1 (n = 9), and CMRO2 was 1.34 ± 0.08 ml O2·100 g-1·min-1 (n = 7). During hyperthermia, total CBF increased by 97 ± 23% and CMRO2 by 65 ± 24%. We also examined whether cerebral resistance vessels were responsive under these conditions. During hyperthermia, total CBF was 63 ± 6 ml·min-1·100 g-1, and CMRO2 was 2.13 ± 0.27 ml O2·100 g-1·min-1. During sustained hyperthermia, intravenous injection of 5 mg/kg of indomethacin decreased total CBF by 45 ± 7% (n = 9), and CMRO2 fell by 55 ± 10% (n = 5). We conclude that 1) hyperthermia increases CBF and CMRO2, and 2) the dilated cerebrovascular bed during hyperthermia still is responsive to a constrictor stimulus.

AB - We examined effects of hyperthermia on cerebral metabolic rate for oxygen (CMRO2) and cerebral blood flow (CBF) in anesthetized, newborn pigs (2-5 days old). CBF and CMRO2 were measured during normothermia (38°C) and during hyperthermia induced by body heating (42°C). During normothermia, total CBF was 32 ± 3 ml·min-1·100 g-1 (n = 9), and CMRO2 was 1.34 ± 0.08 ml O2·100 g-1·min-1 (n = 7). During hyperthermia, total CBF increased by 97 ± 23% and CMRO2 by 65 ± 24%. We also examined whether cerebral resistance vessels were responsive under these conditions. During hyperthermia, total CBF was 63 ± 6 ml·min-1·100 g-1, and CMRO2 was 2.13 ± 0.27 ml O2·100 g-1·min-1. During sustained hyperthermia, intravenous injection of 5 mg/kg of indomethacin decreased total CBF by 45 ± 7% (n = 9), and CMRO2 fell by 55 ± 10% (n = 5). We conclude that 1) hyperthermia increases CBF and CMRO2, and 2) the dilated cerebrovascular bed during hyperthermia still is responsive to a constrictor stimulus.

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