Hypothiocyanite Ion

Detection of the Antimicrobial Agent in Human Saliva

Edwin Thomas, Kate Pera Bates, M. Margaret Jefferson

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The median concentration of hypothiocyanite (OSCN-) in freshly collected whole saliva was 10 μM. The OSCN- concentration increased to a median value of 36 μM during incubation for one h at 37° in vitro. This increase was partially inhibited by adding certain sugars (especially sucrose). The results suggest that OSCN- is a naturally occurring component of human saliva. Also, dietary carbohydrate may inhibit OSCN- accumulation and antimicrobial action in saliva.

Original languageEnglish (US)
Pages (from-to)1466-1472
Number of pages7
JournalJournal of Dental Research
Volume59
Issue number9
DOIs
StatePublished - Jan 1 1980

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Anti-Infective Agents
Saliva
Dietary Carbohydrates
Sucrose
hypothiocyanite ion

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Hypothiocyanite Ion : Detection of the Antimicrobial Agent in Human Saliva. / Thomas, Edwin; Pera Bates, Kate; Jefferson, M. Margaret.

In: Journal of Dental Research, Vol. 59, No. 9, 01.01.1980, p. 1466-1472.

Research output: Contribution to journalArticle

Thomas, Edwin ; Pera Bates, Kate ; Jefferson, M. Margaret. / Hypothiocyanite Ion : Detection of the Antimicrobial Agent in Human Saliva. In: Journal of Dental Research. 1980 ; Vol. 59, No. 9. pp. 1466-1472.
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