Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland

Ilkka Paatero, Tiffany Seagroves, Katri Vaparanta, Wen Han, Frank E. Jones, Randall S. Johnson, Klaus Elenius

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: HIF-1α regulates mammary gland development by an unknown mechanism. Results: HIF-1α promotes ErbB4 protein accumulation, activity, and ErbB4-dependent differentiation of mammary epithelial cells. Conclusion: HIF-1α is a regulator of ErbB4 signaling in vitro and in vivo. Significance: A mechanism involved in the regulation of mammary gland development by HIF-1α is described.

Original languageEnglish (US)
Pages (from-to)22459-22469
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

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Hypoxia-Inducible Factor 1
Human Mammary Glands
Proteins
Breast
Epithelial Cells
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland. / Paatero, Ilkka; Seagroves, Tiffany; Vaparanta, Katri; Han, Wen; Jones, Frank E.; Johnson, Randall S.; Elenius, Klaus.

In: Journal of Biological Chemistry, Vol. 289, No. 32, 08.08.2014, p. 22459-22469.

Research output: Contribution to journalArticle

Paatero, I, Seagroves, T, Vaparanta, K, Han, W, Jones, FE, Johnson, RS & Elenius, K 2014, 'Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22459-22469. https://doi.org/10.1074/jbc.M113.533497
Paatero, Ilkka ; Seagroves, Tiffany ; Vaparanta, Katri ; Han, Wen ; Jones, Frank E. ; Johnson, Randall S. ; Elenius, Klaus. / Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 32. pp. 22459-22469.
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