Hypoxic-ischemic brain injury and the vegetative state: Clinical and neuropathologic correlation

John Dougherty, Donald G. Rawlinson, David E. Levy, Fred Plum

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

We studied 10 patients who survived for 2 to 8 weeks in a vegetative state, including 8 with cardiopulmonary failure and 2 with subarachnoid hemorrhage. Within days of onset, they regained brainstem function and awoke, but none had evidence of cognitive awareness. All patients opened their eyes within 2 weeks, and eight had roving conjugate eye movements. Pupillary and corneal responses were intact within 1 week, and seven patients had tonic oculovestibular responses (OVR) within 24 hours. By the end of 1 day, only three patients failed to move limbs in response to noxious stimuli. At postmortem, all patients had widespread ischemic neuronal damage in the cerebral hemispheres. The brainstems lacked morphologic abnormality, except that one patient had a single microinfarct in the superior colliculus.

Original languageEnglish (US)
Pages (from-to)991-997
Number of pages7
JournalNeurology
Volume31
Issue number8
StatePublished - Jan 1 1981
Externally publishedYes

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Persistent Vegetative State
Brain Injuries
Brain Stem
Superior Colliculi
Cerebrum
Subarachnoid Hemorrhage
Eye Movements
Extremities

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Hypoxic-ischemic brain injury and the vegetative state : Clinical and neuropathologic correlation. / Dougherty, John; Rawlinson, Donald G.; Levy, David E.; Plum, Fred.

In: Neurology, Vol. 31, No. 8, 01.01.1981, p. 991-997.

Research output: Contribution to journalArticle

Dougherty, John ; Rawlinson, Donald G. ; Levy, David E. ; Plum, Fred. / Hypoxic-ischemic brain injury and the vegetative state : Clinical and neuropathologic correlation. In: Neurology. 1981 ; Vol. 31, No. 8. pp. 991-997.
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