Identification of a single QTL, Mptp 1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice

Ruby Cook, Lu Lu, Jing Gu, Robert Williams, Richard Jay Smeyne

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The loss of substantia nigra pars compacta (SNpc) neurons seen in idiopathic Parkinson's disease is hypothesized to result from a genetic susceptibility to an unknown environmental toxin. MPTP has been used as a prototypical toxin, since exposure to this drug results in variable SNpc cell death in several vertebrate species, including man and mouse. Previously, we have shown that C57BL/6J mice are sensitive to this compound, while Swiss-Webster mice are resistant. In this study, we intercrossed these mouse strains to map quantitative trait loci (QTL) for MPTP sensitivity. Using genome wide PCR analysis, we found that a single major QTLs, Mptp1, located near the distal end of chromosome 1 between D1Mit113 and D1Mit293, accounts for the majority of the strain sensitivity to MPTP.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalMolecular Brain Research
Volume110
Issue number2
DOIs
StatePublished - Feb 20 2003

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Quantitative Trait Loci
Neurons
Chromosomes, Human, Pair 1
Genetic Predisposition to Disease
Inbred C57BL Mouse
Parkinson Disease
Vertebrates
Cell Death
Genome
Polymerase Chain Reaction
Pharmaceutical Preparations
Pars Compacta

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Identification of a single QTL, Mptp 1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. / Cook, Ruby; Lu, Lu; Gu, Jing; Williams, Robert; Smeyne, Richard Jay.

In: Molecular Brain Research, Vol. 110, No. 2, 20.02.2003, p. 279-288.

Research output: Contribution to journalArticle

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