Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice

Xiang Ling Tan, Yan Zhou, Ke Fu Cai, Yi Xiang Shao, Shun Xing Zhu, Lu Lu, Robert Williams, Xiao Song Gu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two inbred strains of mice, A/J, C57BL/6J and F2 intercross progenies, were used for QTL mapping for weight and cross-sectional area on cervical enlargement of spinal cord in mice. 13 QTLs located on Chromosome 2, 4, 8, 14, 15, 17, 18, 19 and X, respectively, for these two traits were found. Six QTLs were responsible for the cord weight, four for the cross-sectional area and three for both. Among 13 QTLs, three QTLs (P < 0.01) termed SC1 (located near D15Mit158), SC2 (DXMit140) and SC3 (DXMit64) accounted for 24%, 19% and 15% of the total variance in weight phenotype, and -3.78, 3.41 and 2.06 mg additive effect, respectively. The P value of other QTLs is between 0.01 and 0.05 SC1 is only one QTL that responsible for both weight and cross-sectional area in three QTLs above. This study revealed the location of major QTLs related size of spinal cord in mice, and may be helpful in fine mapping and ultimate identification of candidate genes.

Original languageEnglish (US)
Pages (from-to)801-806
Number of pages6
JournalActa Genetica Sinica
Volume31
Issue number8
StatePublished - Aug 1 2004

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Weights and Measures
Chromosomes, Human, Pair 4
Inbred Strains Mice
Chromosomes, Human, Pair 2
Genetic Association Studies
Spinal Cord
Phenotype
Cervical Cord

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Tan, X. L., Zhou, Y., Cai, K. F., Shao, Y. X., Zhu, S. X., Lu, L., ... Gu, X. S. (2004). Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. Acta Genetica Sinica, 31(8), 801-806.

Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. / Tan, Xiang Ling; Zhou, Yan; Cai, Ke Fu; Shao, Yi Xiang; Zhu, Shun Xing; Lu, Lu; Williams, Robert; Gu, Xiao Song.

In: Acta Genetica Sinica, Vol. 31, No. 8, 01.08.2004, p. 801-806.

Research output: Contribution to journalArticle

Tan, Xiang Ling ; Zhou, Yan ; Cai, Ke Fu ; Shao, Yi Xiang ; Zhu, Shun Xing ; Lu, Lu ; Williams, Robert ; Gu, Xiao Song. / Identification of QTLs for weight and cross-sectional area on cervical enlargement of spinal cord in mice. In: Acta Genetica Sinica. 2004 ; Vol. 31, No. 8. pp. 801-806.
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AU - Cai, Ke Fu

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AU - Lu, Lu

AU - Williams, Robert

AU - Gu, Xiao Song

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