IgA nephropathy in blacks

Studies of IgA2 allotypes and clinical course

Peggy A. Crowley-Nowick, Bruce A. Julian, Robert J. Wyatt, John H. Galla, Barry Wall, David G. Warnock, Jiri Mestecky, Susan Jackson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

IgA nephropathy in Blacks: Studies of IgA2 allotypes and clinical course. The prevalence of IgA nephropathy (IgAN) varies among racial groups, being most common among Caucasians and Orientals and rare in Blacks. Other investigators have hypothesized that the risk for IgAN may be influenced by the IgA2 allotype. It has been suggested that the rare Black patients with IgAN may be homozygous for the A2m(1) allele which predominates in Whites, but is less common in Blacks. In a multicenter study, 27 Black IgAN patients were enrolled to investigate this hypothesis and analyze the clinical course of disease in Blacks. The IgA2 allotypes of 18 Black patients and 14 controls were determined using restriction fragment length polymorphism analysis. Three patients were homozygous for the A2m(1) allele, four were homozygous for A2m(2) and II were heterozygous. The respective allelic frequencies of A2m(1) and A2m(2) were 0.47 and 0.53 and did not differ significantly from Black controls. Most clinical manifestations of disease did not significantly dififer with respect to distribution of the two alleles, although the gender ratio differed between the homozygous A2m(1) and heterozygous patients. The presence of the A2m(1) allele did not increase the risk for IgAN, and the presence of the A2m(2) allele or homozygosity for this allele did not protect Blacks from the development of IgAN.

Original languageEnglish (US)
Pages (from-to)1218-1224
Number of pages7
JournalKidney International
Volume39
Issue number6
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Immunoglobulin A
Alleles
Restriction Fragment Length Polymorphisms
Multicenter Studies
Research Personnel

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Crowley-Nowick, P. A., Julian, B. A., Wyatt, R. J., Galla, J. H., Wall, B., Warnock, D. G., ... Jackson, S. (1991). IgA nephropathy in blacks: Studies of IgA2 allotypes and clinical course. Kidney International, 39(6), 1218-1224. https://doi.org/10.1038/ki.1991.154

IgA nephropathy in blacks : Studies of IgA2 allotypes and clinical course. / Crowley-Nowick, Peggy A.; Julian, Bruce A.; Wyatt, Robert J.; Galla, John H.; Wall, Barry; Warnock, David G.; Mestecky, Jiri; Jackson, Susan.

In: Kidney International, Vol. 39, No. 6, 01.01.1991, p. 1218-1224.

Research output: Contribution to journalArticle

Crowley-Nowick, PA, Julian, BA, Wyatt, RJ, Galla, JH, Wall, B, Warnock, DG, Mestecky, J & Jackson, S 1991, 'IgA nephropathy in blacks: Studies of IgA2 allotypes and clinical course', Kidney International, vol. 39, no. 6, pp. 1218-1224. https://doi.org/10.1038/ki.1991.154
Crowley-Nowick PA, Julian BA, Wyatt RJ, Galla JH, Wall B, Warnock DG et al. IgA nephropathy in blacks: Studies of IgA2 allotypes and clinical course. Kidney International. 1991 Jan 1;39(6):1218-1224. https://doi.org/10.1038/ki.1991.154
Crowley-Nowick, Peggy A. ; Julian, Bruce A. ; Wyatt, Robert J. ; Galla, John H. ; Wall, Barry ; Warnock, David G. ; Mestecky, Jiri ; Jackson, Susan. / IgA nephropathy in blacks : Studies of IgA2 allotypes and clinical course. In: Kidney International. 1991 ; Vol. 39, No. 6. pp. 1218-1224.
@article{e799d9e4ece842c4ab77ca16cc1e431a,
title = "IgA nephropathy in blacks: Studies of IgA2 allotypes and clinical course",
abstract = "IgA nephropathy in Blacks: Studies of IgA2 allotypes and clinical course. The prevalence of IgA nephropathy (IgAN) varies among racial groups, being most common among Caucasians and Orientals and rare in Blacks. Other investigators have hypothesized that the risk for IgAN may be influenced by the IgA2 allotype. It has been suggested that the rare Black patients with IgAN may be homozygous for the A2m(1) allele which predominates in Whites, but is less common in Blacks. In a multicenter study, 27 Black IgAN patients were enrolled to investigate this hypothesis and analyze the clinical course of disease in Blacks. The IgA2 allotypes of 18 Black patients and 14 controls were determined using restriction fragment length polymorphism analysis. Three patients were homozygous for the A2m(1) allele, four were homozygous for A2m(2) and II were heterozygous. The respective allelic frequencies of A2m(1) and A2m(2) were 0.47 and 0.53 and did not differ significantly from Black controls. Most clinical manifestations of disease did not significantly dififer with respect to distribution of the two alleles, although the gender ratio differed between the homozygous A2m(1) and heterozygous patients. The presence of the A2m(1) allele did not increase the risk for IgAN, and the presence of the A2m(2) allele or homozygosity for this allele did not protect Blacks from the development of IgAN.",
author = "Crowley-Nowick, {Peggy A.} and Julian, {Bruce A.} and Wyatt, {Robert J.} and Galla, {John H.} and Barry Wall and Warnock, {David G.} and Jiri Mestecky and Susan Jackson",
year = "1991",
month = "1",
day = "1",
doi = "10.1038/ki.1991.154",
language = "English (US)",
volume = "39",
pages = "1218--1224",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - IgA nephropathy in blacks

T2 - Studies of IgA2 allotypes and clinical course

AU - Crowley-Nowick, Peggy A.

AU - Julian, Bruce A.

AU - Wyatt, Robert J.

AU - Galla, John H.

AU - Wall, Barry

AU - Warnock, David G.

AU - Mestecky, Jiri

AU - Jackson, Susan

PY - 1991/1/1

Y1 - 1991/1/1

N2 - IgA nephropathy in Blacks: Studies of IgA2 allotypes and clinical course. The prevalence of IgA nephropathy (IgAN) varies among racial groups, being most common among Caucasians and Orientals and rare in Blacks. Other investigators have hypothesized that the risk for IgAN may be influenced by the IgA2 allotype. It has been suggested that the rare Black patients with IgAN may be homozygous for the A2m(1) allele which predominates in Whites, but is less common in Blacks. In a multicenter study, 27 Black IgAN patients were enrolled to investigate this hypothesis and analyze the clinical course of disease in Blacks. The IgA2 allotypes of 18 Black patients and 14 controls were determined using restriction fragment length polymorphism analysis. Three patients were homozygous for the A2m(1) allele, four were homozygous for A2m(2) and II were heterozygous. The respective allelic frequencies of A2m(1) and A2m(2) were 0.47 and 0.53 and did not differ significantly from Black controls. Most clinical manifestations of disease did not significantly dififer with respect to distribution of the two alleles, although the gender ratio differed between the homozygous A2m(1) and heterozygous patients. The presence of the A2m(1) allele did not increase the risk for IgAN, and the presence of the A2m(2) allele or homozygosity for this allele did not protect Blacks from the development of IgAN.

AB - IgA nephropathy in Blacks: Studies of IgA2 allotypes and clinical course. The prevalence of IgA nephropathy (IgAN) varies among racial groups, being most common among Caucasians and Orientals and rare in Blacks. Other investigators have hypothesized that the risk for IgAN may be influenced by the IgA2 allotype. It has been suggested that the rare Black patients with IgAN may be homozygous for the A2m(1) allele which predominates in Whites, but is less common in Blacks. In a multicenter study, 27 Black IgAN patients were enrolled to investigate this hypothesis and analyze the clinical course of disease in Blacks. The IgA2 allotypes of 18 Black patients and 14 controls were determined using restriction fragment length polymorphism analysis. Three patients were homozygous for the A2m(1) allele, four were homozygous for A2m(2) and II were heterozygous. The respective allelic frequencies of A2m(1) and A2m(2) were 0.47 and 0.53 and did not differ significantly from Black controls. Most clinical manifestations of disease did not significantly dififer with respect to distribution of the two alleles, although the gender ratio differed between the homozygous A2m(1) and heterozygous patients. The presence of the A2m(1) allele did not increase the risk for IgAN, and the presence of the A2m(2) allele or homozygosity for this allele did not protect Blacks from the development of IgAN.

UR - http://www.scopus.com/inward/record.url?scp=0025916816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025916816&partnerID=8YFLogxK

U2 - 10.1038/ki.1991.154

DO - 10.1038/ki.1991.154

M3 - Article

VL - 39

SP - 1218

EP - 1224

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 6

ER -