IGF2 genotype and obesity in men and women across the adult age span

S. M. Roth, M. A. Schrager, E. Metter, S. E. Riechman, J. L. Fleg, B. F. Hurley, R. E. Ferrell

Research output: Contribution to journalArticle

Abstract

We studied a previously reported association between the IGF2 gene's Apal polymorphism and obesity in 500 healthy men and women (19-90 y). We hypothesized that individuals homozygous for the IGF2 A allele (A/A) would exhibit lower body mass, BMI and DEXA-measured fat mass compared to G/G homozygotes. Subjects were categorized as exhibiting the G/G (n = 241), G/A (n = 197) or A/A (n = 62) genotype. Contrary to our hypothesis, no difference was observed in body mass, body mass index (BMI) or fat mass between the G/G and A/A genotype groups in the entire cohort. Surprisingly, Caucasian A/A individuals (n = 427) exhibited significantly higher fat mass compared to Caucasian G/G individuals (P < 0.05). In summary, individuals homozygous for the IGF2 G allele do not exhibit higher body mass, BMI or fat mass compared to A/A individuals; however, Caucasians with the A/A genotype exhibit higher fat mass than G/G individuals.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalInternational Journal of Obesity
Volume26
Issue number4
DOIs
StatePublished - Jan 1 2002

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Obesity
Alleles
Genotype
Fats
Body Mass Index
Homozygote
Genes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Roth, S. M., Schrager, M. A., Metter, E., Riechman, S. E., Fleg, J. L., Hurley, B. F., & Ferrell, R. E. (2002). IGF2 genotype and obesity in men and women across the adult age span. International Journal of Obesity, 26(4), 585-587. https://doi.org/10.1038/sj.ijo.0801927

IGF2 genotype and obesity in men and women across the adult age span. / Roth, S. M.; Schrager, M. A.; Metter, E.; Riechman, S. E.; Fleg, J. L.; Hurley, B. F.; Ferrell, R. E.

In: International Journal of Obesity, Vol. 26, No. 4, 01.01.2002, p. 585-587.

Research output: Contribution to journalArticle

Roth, SM, Schrager, MA, Metter, E, Riechman, SE, Fleg, JL, Hurley, BF & Ferrell, RE 2002, 'IGF2 genotype and obesity in men and women across the adult age span', International Journal of Obesity, vol. 26, no. 4, pp. 585-587. https://doi.org/10.1038/sj.ijo.0801927
Roth, S. M. ; Schrager, M. A. ; Metter, E. ; Riechman, S. E. ; Fleg, J. L. ; Hurley, B. F. ; Ferrell, R. E. / IGF2 genotype and obesity in men and women across the adult age span. In: International Journal of Obesity. 2002 ; Vol. 26, No. 4. pp. 585-587.
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