IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection

Tony Marion, A. L.M. Bothwell, D. E. Briles, C. A. Janeway

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Although mice from almost all inbred strains produce IgM anti-DNA antibody in response to B cell mitogens, only (NZB x NZW)F1 mice and mice from other strains that are genetically predisposed to autoimmunity spontaneously produce anti-DNA antibody of the IgG isotype. Because (NZB x NZW)F1 mice display marked B cell hyperactivity, anti-DNA antibody production in these mice has been thought to result from spontaneous, polyclonal B cell activation. Although this may be true for IgM anti-DNA antibodies, our results demonstrate that IgG anti-DNA antibodies are not polyclonal. Rather, IgG anti-DNA autoantibodies within an individual autoimmune mouse are oligoclonal and somatically mutated. These results demonstrate that IgG anti-DNA autoantibodies are the products of clonally selective B cell stimulation and exhibit the same characteristics as secondary immune antibodies to conventional immunogens: they are IgG, they are clonally restricted, and they are somatically mutated.

Original languageEnglish (US)
Pages (from-to)4269-4274
Number of pages6
JournalJournal of Immunology
Volume142
Issue number12
StatePublished - Jan 1 1989
Externally publishedYes

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Autoantibodies
Antinuclear Antibodies
DNA
B-Lymphocytes
Immunoglobulin G
Antibody Formation
Immunoglobulin M
Autoimmunity
Mitogens
anti-IgG
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. / Marion, Tony; Bothwell, A. L.M.; Briles, D. E.; Janeway, C. A.

In: Journal of Immunology, Vol. 142, No. 12, 01.01.1989, p. 4269-4274.

Research output: Contribution to journalArticle

Marion, Tony ; Bothwell, A. L.M. ; Briles, D. E. ; Janeway, C. A. / IgG anti-DNA autoantibodies within an individual autoimmune mouse are the products of clonal selection. In: Journal of Immunology. 1989 ; Vol. 142, No. 12. pp. 4269-4274.
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