IgM anti‐histone H‐3 antibody associated with undifferentiated rheumatic disease syndromes

Daniel P. Molden, Gary Klipple, Carol L. Peebles, Robert L. Rubin, Robert M. Nakamura, Eng M. Tan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A distinctive type of speckled antinuclear antibody staining pattern was identified by indirect immunofluorescence on mouse kidney substrate in 4.8% of 5,976 specimens analyzed for antinuclear antibodies. This pattern, termed variable large speckles (VLS), consisted of 3–10 nuclear speckles ranging in size from approximately 0.2–2.0μ. The pattern could be differentiated from other indirect immunofluorescence patterns related to specific antibodies. The predominant immunoglobulin isotype demonstrating the VLS pattern was IgM in 27 of 28 sera examined and IgG in 1 serum. VLS sera had substantial IgM antibodies to histone demonstrated by enzyme immunoassay, and further analysis of representative sera showed predominant antibody activity to histone class 3 (H‐3). Adsorption with histone H‐3 resulted in decrease or removal of antibody producing the VLS pattern. Available information showed that most patients with IgM antibodies of the VLS pattern had undifferentiated connective tissue disease symptoms. They were characterized by a heterogeneity of chronic symptoms including arthralgias, myalgias, inflammatory polyarthritis, myositis, sicca symptoms, and pleurisy associated with elevation of the erythrocyte sedimentation rate. It remains to be determined whether the IgM anti‐histone H‐3 profile of these patients is a transient or long‐standing serologic characteristic.

Original languageEnglish (US)
Pages (from-to)39-46
Number of pages8
JournalArthritis & Rheumatism
Volume29
Issue number1
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Immunoglobulin Isotypes
Rheumatic Diseases
Histones
Immunoglobulin M
Antibodies
Antinuclear Antibodies
Indirect Fluorescent Antibody Technique
Serum
Pleurisy
Myositis
Connective Tissue Diseases
Blood Sedimentation
Myalgia
Arthralgia
Immunoenzyme Techniques
Adsorption
Arthritis
Immunoglobulin G
Staining and Labeling
Kidney

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

IgM anti‐histone H‐3 antibody associated with undifferentiated rheumatic disease syndromes. / Molden, Daniel P.; Klipple, Gary; Peebles, Carol L.; Rubin, Robert L.; Nakamura, Robert M.; Tan, Eng M.

In: Arthritis & Rheumatism, Vol. 29, No. 1, 01.01.1986, p. 39-46.

Research output: Contribution to journalArticle

Molden, Daniel P. ; Klipple, Gary ; Peebles, Carol L. ; Rubin, Robert L. ; Nakamura, Robert M. ; Tan, Eng M. / IgM anti‐histone H‐3 antibody associated with undifferentiated rheumatic disease syndromes. In: Arthritis & Rheumatism. 1986 ; Vol. 29, No. 1. pp. 39-46.
@article{3eb8117cee5b4c7aa76a375b194209af,
title = "IgM anti‐histone H‐3 antibody associated with undifferentiated rheumatic disease syndromes",
abstract = "A distinctive type of speckled antinuclear antibody staining pattern was identified by indirect immunofluorescence on mouse kidney substrate in 4.8{\%} of 5,976 specimens analyzed for antinuclear antibodies. This pattern, termed variable large speckles (VLS), consisted of 3–10 nuclear speckles ranging in size from approximately 0.2–2.0μ. The pattern could be differentiated from other indirect immunofluorescence patterns related to specific antibodies. The predominant immunoglobulin isotype demonstrating the VLS pattern was IgM in 27 of 28 sera examined and IgG in 1 serum. VLS sera had substantial IgM antibodies to histone demonstrated by enzyme immunoassay, and further analysis of representative sera showed predominant antibody activity to histone class 3 (H‐3). Adsorption with histone H‐3 resulted in decrease or removal of antibody producing the VLS pattern. Available information showed that most patients with IgM antibodies of the VLS pattern had undifferentiated connective tissue disease symptoms. They were characterized by a heterogeneity of chronic symptoms including arthralgias, myalgias, inflammatory polyarthritis, myositis, sicca symptoms, and pleurisy associated with elevation of the erythrocyte sedimentation rate. It remains to be determined whether the IgM anti‐histone H‐3 profile of these patients is a transient or long‐standing serologic characteristic.",
author = "Molden, {Daniel P.} and Gary Klipple and Peebles, {Carol L.} and Rubin, {Robert L.} and Nakamura, {Robert M.} and Tan, {Eng M.}",
year = "1986",
month = "1",
day = "1",
doi = "10.1002/art.1780290106",
language = "English (US)",
volume = "29",
pages = "39--46",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - IgM anti‐histone H‐3 antibody associated with undifferentiated rheumatic disease syndromes

AU - Molden, Daniel P.

AU - Klipple, Gary

AU - Peebles, Carol L.

AU - Rubin, Robert L.

AU - Nakamura, Robert M.

AU - Tan, Eng M.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - A distinctive type of speckled antinuclear antibody staining pattern was identified by indirect immunofluorescence on mouse kidney substrate in 4.8% of 5,976 specimens analyzed for antinuclear antibodies. This pattern, termed variable large speckles (VLS), consisted of 3–10 nuclear speckles ranging in size from approximately 0.2–2.0μ. The pattern could be differentiated from other indirect immunofluorescence patterns related to specific antibodies. The predominant immunoglobulin isotype demonstrating the VLS pattern was IgM in 27 of 28 sera examined and IgG in 1 serum. VLS sera had substantial IgM antibodies to histone demonstrated by enzyme immunoassay, and further analysis of representative sera showed predominant antibody activity to histone class 3 (H‐3). Adsorption with histone H‐3 resulted in decrease or removal of antibody producing the VLS pattern. Available information showed that most patients with IgM antibodies of the VLS pattern had undifferentiated connective tissue disease symptoms. They were characterized by a heterogeneity of chronic symptoms including arthralgias, myalgias, inflammatory polyarthritis, myositis, sicca symptoms, and pleurisy associated with elevation of the erythrocyte sedimentation rate. It remains to be determined whether the IgM anti‐histone H‐3 profile of these patients is a transient or long‐standing serologic characteristic.

AB - A distinctive type of speckled antinuclear antibody staining pattern was identified by indirect immunofluorescence on mouse kidney substrate in 4.8% of 5,976 specimens analyzed for antinuclear antibodies. This pattern, termed variable large speckles (VLS), consisted of 3–10 nuclear speckles ranging in size from approximately 0.2–2.0μ. The pattern could be differentiated from other indirect immunofluorescence patterns related to specific antibodies. The predominant immunoglobulin isotype demonstrating the VLS pattern was IgM in 27 of 28 sera examined and IgG in 1 serum. VLS sera had substantial IgM antibodies to histone demonstrated by enzyme immunoassay, and further analysis of representative sera showed predominant antibody activity to histone class 3 (H‐3). Adsorption with histone H‐3 resulted in decrease or removal of antibody producing the VLS pattern. Available information showed that most patients with IgM antibodies of the VLS pattern had undifferentiated connective tissue disease symptoms. They were characterized by a heterogeneity of chronic symptoms including arthralgias, myalgias, inflammatory polyarthritis, myositis, sicca symptoms, and pleurisy associated with elevation of the erythrocyte sedimentation rate. It remains to be determined whether the IgM anti‐histone H‐3 profile of these patients is a transient or long‐standing serologic characteristic.

UR - http://www.scopus.com/inward/record.url?scp=0022917629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022917629&partnerID=8YFLogxK

U2 - 10.1002/art.1780290106

DO - 10.1002/art.1780290106

M3 - Article

VL - 29

SP - 39

EP - 46

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 1

ER -