Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy

Noah D. Sabin, T. E. Merchant, J. H. Harreld, Z. Patay, Paul Klimo, I. Qaddoumi, Gregory Armstrong, K. Wright, J. Gray, D. J. Indelicato, A. Gajjar

Research output: Contribution to journalArticle

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Abstract

PT promises to reduce side effects in children with brain tumors by sparing normal tissue compared with 3D conformal or intensity-modulated radiation therapy. Information is lacking about the combined effects of PT and chemotherapy in young children. We describe imaging changes in 8 very young children with localized brain tumors who received PT after chemotherapy. Mostly transient signal abnormalities and enhancement in brain parenchyma were observed by serial MR imaging, which were consistent with radiation-induced effects on normal-appearing tissue. Correlation with PT planning data revealed that the areas of imaging abnormality were located within or adjacent to the volume that received the highest radiation dose. Radiologists should be aware of these findings in children who receive PT after chemotherapy. In this report, we describe the time course of these PT-related imaging findings and correlate them with treatment and clinical outcomes.

Original languageEnglish (US)
Pages (from-to)446-450
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume34
Issue number2
DOIs
StatePublished - Feb 1 2013

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Proton Therapy
Brain Neoplasms
Drug Therapy
Radiation Effects
Radiotherapy
Radiation
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

Cite this

Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy. / Sabin, Noah D.; Merchant, T. E.; Harreld, J. H.; Patay, Z.; Klimo, Paul; Qaddoumi, I.; Armstrong, Gregory; Wright, K.; Gray, J.; Indelicato, D. J.; Gajjar, A.

In: American Journal of Neuroradiology, Vol. 34, No. 2, 01.02.2013, p. 446-450.

Research output: Contribution to journalArticle

Sabin, ND, Merchant, TE, Harreld, JH, Patay, Z, Klimo, P, Qaddoumi, I, Armstrong, G, Wright, K, Gray, J, Indelicato, DJ & Gajjar, A 2013, 'Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy', American Journal of Neuroradiology, vol. 34, no. 2, pp. 446-450. https://doi.org/10.3174/ajnr.A3219
Sabin, Noah D. ; Merchant, T. E. ; Harreld, J. H. ; Patay, Z. ; Klimo, Paul ; Qaddoumi, I. ; Armstrong, Gregory ; Wright, K. ; Gray, J. ; Indelicato, D. J. ; Gajjar, A. / Imaging changes in very young children with brain tumors treated with proton therapy and chemotherapy. In: American Journal of Neuroradiology. 2013 ; Vol. 34, No. 2. pp. 446-450.
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