Immunoblastic B-cell Malignant Lymphoma Involving the Orbit and Maxillary Sinus in a Patient with Acquired Immune Deficiency Syndrome

Ramon L. Font, Rodolfo Laucirica, James R. Patrinely

Research output: Contribution to journalArticle

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Abstract

Background: A 44-year-old man was diagnosed with acquired inmmune deficiency syndrome (AIDS)-related complex in 1986. Four years later, erythema and swelling of the right lower eyelid and face and a palpable mass along the right inferior orbital rim developed. Computed tomographic scans of the orbits disclosed a mass involving the right superior antrum and inferior orbit. Histopathologic examination and immunohistochemical studies of the tumor were performed. Methods: Immunohistochemical studies were performed on paraffin sections of the neoplasm. Markers used included leukocyte-common antigen and L26 (pan B-cell marker), and MT1, Leu22, polyclonal CD3, UCHL-1, and OPD4 (pan T-cell markers). Additional markers included cytokeratin, HMB-45, lysozyme, S-100 protein, kappa, and lambda. Findings: The neoplastic cells were strongly to moderately positive with LCA, L26, MT1, and Leu22. Negative staining was observed with the remaining nine antibodies. Conclusion: Orbital lymphomas in patients with AIDS have been rarely documented; those few reported cases showed a B-cell phenotype. The authors report an immunoblastic B cell with immunophenotypic coexpression of T-cell markers.

Original languageEnglish (US)
Pages (from-to)966-970
Number of pages5
JournalOphthalmology
Volume100
Issue number6
DOIs
StatePublished - Jan 1 1993

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Maxillary Sinus
B-Cell Lymphoma
Lymphoma
Acquired Immunodeficiency Syndrome
B-Lymphocytes
Orbit
CD45 Antigens
T-Lymphocytes
Negative Staining
S100 Proteins
Eyelids
Erythema
Muramidase
Keratins
Paraffin
Neoplasms
Phenotype
Antibodies
Orbital lymphoma

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Immunoblastic B-cell Malignant Lymphoma Involving the Orbit and Maxillary Sinus in a Patient with Acquired Immune Deficiency Syndrome. / Font, Ramon L.; Laucirica, Rodolfo; Patrinely, James R.

In: Ophthalmology, Vol. 100, No. 6, 01.01.1993, p. 966-970.

Research output: Contribution to journalArticle

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