Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke

Orie Saino, Akihiko Taguchi, Takayuki Nakagomi, Akiko Nakano-Doi, Shin Ichiro Kashiwamura, Nobutaka Doe, Nami Nakagomi, Toshihiro Soma, Hiroo Yoshikawa, David Stern, Haruki Okamura, Tomohiro Matsuyama

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Acute inflammation in the poststroke period exacerbates neuronal damage and stimulates reparative mechanisms, including neurogenesis. However, only a small fraction of neural stem/progenitor cells survives. In this report, by using a highly reproducible model of cortical infarction in SCID mice, we examined the effects of immunodeficiency on reduction of brain injury, survival of neural stem/progenitor cells, and functional recovery. Subsequently, the contribution of T lymphocytes to neurogenesis was evaluated in mice depleted for each subset of T lymphocyte. SCID mice revealed the reduced apoptosis and enhanced proliferation of neural stem/progenitor cells induced by cerebral cortex after stroke compared with the immunocompetent wild-type mice. Removal of T lymphocytes, especially the CD4+ T-cell population, enhanced generation of neural stem/progenitor cells, followed by accelerated functional recovery. In contrast, removal of CD25+ T cells, a cell population including regulatory T lymphocytes, impaired functional recovery through, at least in part, suppression of neurogenesis. Our findings demonstrate a key role of T lymphocytes in regulation of poststroke neurogenesis and indicate a potential novel strategy for cell therapy in repair of the central nervous system.

Original languageEnglish (US)
Pages (from-to)2385-2397
Number of pages13
JournalJournal of Neuroscience Research
Volume88
Issue number11
DOIs
StatePublished - Aug 15 2010
Externally publishedYes

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Neural Stem Cells
Neurogenesis
Cerebral Cortex
Stem Cells
Stroke
Apoptosis
T-Lymphocytes
SCID Mice
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
Cell- and Tissue-Based Therapy
Brain Injuries
Infarction
Population
Central Nervous System
Inflammation

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

Cite this

Saino, O., Taguchi, A., Nakagomi, T., Nakano-Doi, A., Kashiwamura, S. I., Doe, N., ... Matsuyama, T. (2010). Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke. Journal of Neuroscience Research, 88(11), 2385-2397. https://doi.org/10.1002/jnr.22410

Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke. / Saino, Orie; Taguchi, Akihiko; Nakagomi, Takayuki; Nakano-Doi, Akiko; Kashiwamura, Shin Ichiro; Doe, Nobutaka; Nakagomi, Nami; Soma, Toshihiro; Yoshikawa, Hiroo; Stern, David; Okamura, Haruki; Matsuyama, Tomohiro.

In: Journal of Neuroscience Research, Vol. 88, No. 11, 15.08.2010, p. 2385-2397.

Research output: Contribution to journalArticle

Saino, O, Taguchi, A, Nakagomi, T, Nakano-Doi, A, Kashiwamura, SI, Doe, N, Nakagomi, N, Soma, T, Yoshikawa, H, Stern, D, Okamura, H & Matsuyama, T 2010, 'Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke', Journal of Neuroscience Research, vol. 88, no. 11, pp. 2385-2397. https://doi.org/10.1002/jnr.22410
Saino, Orie ; Taguchi, Akihiko ; Nakagomi, Takayuki ; Nakano-Doi, Akiko ; Kashiwamura, Shin Ichiro ; Doe, Nobutaka ; Nakagomi, Nami ; Soma, Toshihiro ; Yoshikawa, Hiroo ; Stern, David ; Okamura, Haruki ; Matsuyama, Tomohiro. / Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke. In: Journal of Neuroscience Research. 2010 ; Vol. 88, No. 11. pp. 2385-2397.
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