Immunosuppressive agents in corticosteroid-refractory childhood dermatomyositis

Enayatolah Niakan, Samuel E. Pitner, John N. Whitaker, Tulio Bertorini

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Five patients with childhood dermatomyositis, followed for 18 to 96 months, improved when treated with a combination of corticosteroids and methotrexate (one patient) or corticosteroids and cyclophosphamide (four patients) after having become refractory to corticosteroid therapy alone. Complications of vascular involvement in childhood dermatomyositis or from immunosuppressive therapy were observed in most of these patients. Disease components involving skin, muscle, or systemic vessels sometimes varied independently in regard to disease activity or therapeutic responsiveness. In two patients with stable or improving muscle function, cerebrovascular complications occurred. Monitoring of disease activity was best accomplished by clinical evaluation; serum muscle enzymes usually failed to rise prior to or during periods of clinical worsening.

Original languageEnglish (US)
Pages (from-to)286-291
Number of pages6
JournalNeurology
Volume30
Issue number3
StatePublished - Jan 1 1980

Fingerprint

Dermatomyositis
Immunosuppressive Agents
Adrenal Cortex Hormones
Muscles
Methotrexate
Cyclophosphamide
Blood Vessels
Therapeutics
Skin
Enzymes
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Niakan, E., Pitner, S. E., Whitaker, J. N., & Bertorini, T. (1980). Immunosuppressive agents in corticosteroid-refractory childhood dermatomyositis. Neurology, 30(3), 286-291.

Immunosuppressive agents in corticosteroid-refractory childhood dermatomyositis. / Niakan, Enayatolah; Pitner, Samuel E.; Whitaker, John N.; Bertorini, Tulio.

In: Neurology, Vol. 30, No. 3, 01.01.1980, p. 286-291.

Research output: Contribution to journalArticle

Niakan, E, Pitner, SE, Whitaker, JN & Bertorini, T 1980, 'Immunosuppressive agents in corticosteroid-refractory childhood dermatomyositis', Neurology, vol. 30, no. 3, pp. 286-291.
Niakan, Enayatolah ; Pitner, Samuel E. ; Whitaker, John N. ; Bertorini, Tulio. / Immunosuppressive agents in corticosteroid-refractory childhood dermatomyositis. In: Neurology. 1980 ; Vol. 30, No. 3. pp. 286-291.
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