Impact of Combination Antibiogram and Related Education on Inpatient Fluoroquinolone Prescribing Patterns for Patients With Health Care–Associated Pneumonia

Baoqi Liang, James Wheeler, Lisa M. Blanchette

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Previous studies have shown that development of a unit-specific combination antibiogram improves optimal selection of empiric therapy for Gram-negative infections, yet no published data exist regarding the role of the combination antibiogram as an antimicrobial stewardship program tool for disease-specific prescribing. Objective: To evaluate the utility of a combination antibiogram to guide antibiotic prescribing for patients with health care–associated pneumonia (HCAP). Methods: This was a retrospective preprovider and postprovider education intervention study aimed to evaluate fluoroquinolone (FQ) use in patients with HCAP. Data were collected retrospectively to evaluate antibiotic prescribing patterns and patient outcomes. Results: A total of 87 patients were eligible for study inclusion. The primary end point, FQ days of therapy (DOT) was decreased by 2.3 days (P < 0.001). The secondary end point included FQ DOT per 1000 patient-days in patients with discharge diagnosis-related group of pneumonia and was decreased by 83.5 days (P = 0.08); double coverage reduced by 13% postintervention (P = 0.22); mean days of double coverage decreased by 2.1 days (P < 0.001), and length of stay was shortened by 2.1 days (P = 0.22). Clinical success was achieved more often in the postintervention group (90% vs 98%, P = 0.18) when compared with the preintervention group. No difference was found in microbiological outcomes in the subset of microbiologically evaluable patients (P = 0.57). Conclusion: Facility-specific combination antibiograms may be used to inform antibiotic prescribing in HCAP patients.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalAnnals of Pharmacotherapy
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

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Fluoroquinolones
Microbial Sensitivity Tests
Inpatients
Pneumonia
Education
Health
Anti-Bacterial Agents
Patient Discharge
Diagnosis-Related Groups
Length of Stay
Therapeutics
Infection

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Impact of Combination Antibiogram and Related Education on Inpatient Fluoroquinolone Prescribing Patterns for Patients With Health Care–Associated Pneumonia. / Liang, Baoqi; Wheeler, James; Blanchette, Lisa M.

In: Annals of Pharmacotherapy, Vol. 50, No. 3, 01.03.2016, p. 172-179.

Research output: Contribution to journalArticle

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