Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients – results from VISTA

for the VISTA collaborators

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and purpose: Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke patients is less well established. We investigated the effects of HR on admission in acute ischaemic stroke patients. Methods: Using the Virtual International Stroke Trials Archive (VISTA) database, the association between HR in acute stroke patients without atrial fibrillation and the pre-defined composite end-point of (recurrent) ischaemic stroke, transient ischaemic attack (TIA), myocardial infarction (MI) and vascular death within 90 days was analysed. Pre-defined secondary outcomes were the composite end-point components and any death, decompensated heart failure and degree of functional dependence according to the modified Rankin Scale after 90 days. HR was analysed as a categorical variable (quartiles). Results: In all, 5606 patients were available for analysis (mean National Institutes of Health Stroke Scale 13; mean age 67 years; mean HR 77 bpm; 44% female) amongst whom the composite end-point occurred in 620 patients (11.1%). Higher HR was not associated with the composite end-point. The frequencies of secondary outcomes were 3.2% recurrent stroke (n = 179), 0.6% TIA (n = 35), 1.8% MI (n = 100), 6.8% vascular death (n = 384), 15.0% any death (n = 841) and 2.2% decompensated heart failure (n = 124). Patients in the highest quartile (HR> 86 bpm) were at increased risk for any death [adjusted hazard ratio (95% confidence interval) 1.40 (1.11–1.75)], decompensated heart failure [adjusted hazard ratio 2.20 (1.11–4.37)] and worse modified Rankin Scale [adjusted odds ratio 1.29 (1.14–1.52)]. Conclusions: In acute stroke patients, higher HR (>86 bpm) is linked to mortality, heart failure and higher degree of dependence after 90 days but not to recurrent stroke, TIA or MI.

Original languageEnglish (US)
Pages (from-to)1750-1756
Number of pages7
JournalEuropean Journal of Neurology
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2016

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Heart Rate
Stroke
Morbidity
Mortality
Transient Ischemic Attack
Heart Failure
Myocardial Infarction
Blood Vessels
National Institutes of Health (U.S.)
Atrial Fibrillation
Cardiovascular Diseases
Odds Ratio
Databases
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients – results from VISTA. / for the VISTA collaborators.

In: European Journal of Neurology, Vol. 23, No. 12, 01.12.2016, p. 1750-1756.

Research output: Contribution to journalArticle

@article{b44e340eef6c4b35baff18a24c704a84,
title = "Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients – results from VISTA",
abstract = "Background and purpose: Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke patients is less well established. We investigated the effects of HR on admission in acute ischaemic stroke patients. Methods: Using the Virtual International Stroke Trials Archive (VISTA) database, the association between HR in acute stroke patients without atrial fibrillation and the pre-defined composite end-point of (recurrent) ischaemic stroke, transient ischaemic attack (TIA), myocardial infarction (MI) and vascular death within 90 days was analysed. Pre-defined secondary outcomes were the composite end-point components and any death, decompensated heart failure and degree of functional dependence according to the modified Rankin Scale after 90 days. HR was analysed as a categorical variable (quartiles). Results: In all, 5606 patients were available for analysis (mean National Institutes of Health Stroke Scale 13; mean age 67 years; mean HR 77 bpm; 44{\%} female) amongst whom the composite end-point occurred in 620 patients (11.1{\%}). Higher HR was not associated with the composite end-point. The frequencies of secondary outcomes were 3.2{\%} recurrent stroke (n = 179), 0.6{\%} TIA (n = 35), 1.8{\%} MI (n = 100), 6.8{\%} vascular death (n = 384), 15.0{\%} any death (n = 841) and 2.2{\%} decompensated heart failure (n = 124). Patients in the highest quartile (HR> 86 bpm) were at increased risk for any death [adjusted hazard ratio (95{\%} confidence interval) 1.40 (1.11–1.75)], decompensated heart failure [adjusted hazard ratio 2.20 (1.11–4.37)] and worse modified Rankin Scale [adjusted odds ratio 1.29 (1.14–1.52)]. Conclusions: In acute stroke patients, higher HR (>86 bpm) is linked to mortality, heart failure and higher degree of dependence after 90 days but not to recurrent stroke, TIA or MI.",
author = "{for the VISTA collaborators} and Nolte, {C. H.} and H. Erdur and U. Grittner and A. Schneider and Piper, {S. K.} and Scheitz, {J. F.} and I. Wellwood and Bath, {P. M.W.} and Diener, {H. C.} and Lees, {K. R.} and M. Endres and A. Alexandrov and Andrei Alexandrov and N. Bornstein and C. Chen and L. Claesson and Davis, {S. M.} and G. Donnan and M. Fisher and M. Ginsberg and B. Gregson and J. Grotta and W. Hacke and Hennerici, {M. G.} and M. Hommel and M. Kaste and P. Lyden and J. Marler and K. Muir and R. Sacco and A. Shuaib and P. Teal and N. Venketasubramanian and Wahlgren, {N. G.} and S. Warach and C. Weimar",
year = "2016",
month = "12",
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TY - JOUR

T1 - Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients – results from VISTA

AU - for the VISTA collaborators

AU - Nolte, C. H.

AU - Erdur, H.

AU - Grittner, U.

AU - Schneider, A.

AU - Piper, S. K.

AU - Scheitz, J. F.

AU - Wellwood, I.

AU - Bath, P. M.W.

AU - Diener, H. C.

AU - Lees, K. R.

AU - Endres, M.

AU - Alexandrov, A.

AU - Alexandrov, Andrei

AU - Bornstein, N.

AU - Chen, C.

AU - Claesson, L.

AU - Davis, S. M.

AU - Donnan, G.

AU - Fisher, M.

AU - Ginsberg, M.

AU - Gregson, B.

AU - Grotta, J.

AU - Hacke, W.

AU - Hennerici, M. G.

AU - Hommel, M.

AU - Kaste, M.

AU - Lyden, P.

AU - Marler, J.

AU - Muir, K.

AU - Sacco, R.

AU - Shuaib, A.

AU - Teal, P.

AU - Venketasubramanian, N.

AU - Wahlgren, N. G.

AU - Warach, S.

AU - Weimar, C.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and purpose: Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke patients is less well established. We investigated the effects of HR on admission in acute ischaemic stroke patients. Methods: Using the Virtual International Stroke Trials Archive (VISTA) database, the association between HR in acute stroke patients without atrial fibrillation and the pre-defined composite end-point of (recurrent) ischaemic stroke, transient ischaemic attack (TIA), myocardial infarction (MI) and vascular death within 90 days was analysed. Pre-defined secondary outcomes were the composite end-point components and any death, decompensated heart failure and degree of functional dependence according to the modified Rankin Scale after 90 days. HR was analysed as a categorical variable (quartiles). Results: In all, 5606 patients were available for analysis (mean National Institutes of Health Stroke Scale 13; mean age 67 years; mean HR 77 bpm; 44% female) amongst whom the composite end-point occurred in 620 patients (11.1%). Higher HR was not associated with the composite end-point. The frequencies of secondary outcomes were 3.2% recurrent stroke (n = 179), 0.6% TIA (n = 35), 1.8% MI (n = 100), 6.8% vascular death (n = 384), 15.0% any death (n = 841) and 2.2% decompensated heart failure (n = 124). Patients in the highest quartile (HR> 86 bpm) were at increased risk for any death [adjusted hazard ratio (95% confidence interval) 1.40 (1.11–1.75)], decompensated heart failure [adjusted hazard ratio 2.20 (1.11–4.37)] and worse modified Rankin Scale [adjusted odds ratio 1.29 (1.14–1.52)]. Conclusions: In acute stroke patients, higher HR (>86 bpm) is linked to mortality, heart failure and higher degree of dependence after 90 days but not to recurrent stroke, TIA or MI.

AB - Background and purpose: Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke patients is less well established. We investigated the effects of HR on admission in acute ischaemic stroke patients. Methods: Using the Virtual International Stroke Trials Archive (VISTA) database, the association between HR in acute stroke patients without atrial fibrillation and the pre-defined composite end-point of (recurrent) ischaemic stroke, transient ischaemic attack (TIA), myocardial infarction (MI) and vascular death within 90 days was analysed. Pre-defined secondary outcomes were the composite end-point components and any death, decompensated heart failure and degree of functional dependence according to the modified Rankin Scale after 90 days. HR was analysed as a categorical variable (quartiles). Results: In all, 5606 patients were available for analysis (mean National Institutes of Health Stroke Scale 13; mean age 67 years; mean HR 77 bpm; 44% female) amongst whom the composite end-point occurred in 620 patients (11.1%). Higher HR was not associated with the composite end-point. The frequencies of secondary outcomes were 3.2% recurrent stroke (n = 179), 0.6% TIA (n = 35), 1.8% MI (n = 100), 6.8% vascular death (n = 384), 15.0% any death (n = 841) and 2.2% decompensated heart failure (n = 124). Patients in the highest quartile (HR> 86 bpm) were at increased risk for any death [adjusted hazard ratio (95% confidence interval) 1.40 (1.11–1.75)], decompensated heart failure [adjusted hazard ratio 2.20 (1.11–4.37)] and worse modified Rankin Scale [adjusted odds ratio 1.29 (1.14–1.52)]. Conclusions: In acute stroke patients, higher HR (>86 bpm) is linked to mortality, heart failure and higher degree of dependence after 90 days but not to recurrent stroke, TIA or MI.

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U2 - 10.1111/ene.13115

DO - 10.1111/ene.13115

M3 - Article

VL - 23

SP - 1750

EP - 1756

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 12

ER -