Impact of individual physicians on enrollment of patients into clinical trials

Robert S. Mannel, Joan L. Walker, Natalie Gould, Dennis R. Scribner, Scott Kamelle, Todd Tillmanns, D. Scott McMeekin, Michael A. Gold

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The National Cancer Institute is committed to increasing enrollment of cancer patients in clinical treatment trials. The factors that achieve successful results are poorly understood. This study analyzes the role of individual physicians in recruitment of patients in clinical trials. A retrospective review was undertaken of all patients with untreated endometrial, cervical, or ovarian cancer potentially eligible for a multi-institutional phase III trial cared for by the Section of Gynecologic Oncology at the University of Oklahoma from July 1, 1998 to September 30, 1999. Patient variables assessed included age, insurance status, cancer diagnosis, and enrollment onto clinical trial. There was no difference in faculty patients with regard to cancer type, age, or insurance status. There was a significant difference (p < 0.01) between faculty in offering protocol therapy and likelihood of successfully enrolling patients. Successful enrollment was correlated with faculty experience and principal investigator status. This study shows that availability of patients, patient variances, support staff, and institutional commitment are secondary to individual physician factors in determining successful enrollment of patients onto clinical trials.

Original languageEnglish (US)
Pages (from-to)171-173
Number of pages3
JournalAmerican Journal of Clinical Oncology
Volume26
Issue number2
DOIs
StatePublished - Apr 2003
Externally publishedYes

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Clinical Trials
Physicians
Insurance Coverage
Physician's Role
Neoplasms
National Cancer Institute (U.S.)
Endometrial Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Patient Selection
Research Personnel
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Impact of individual physicians on enrollment of patients into clinical trials. / Mannel, Robert S.; Walker, Joan L.; Gould, Natalie; Scribner, Dennis R.; Kamelle, Scott; Tillmanns, Todd; McMeekin, D. Scott; Gold, Michael A.

In: American Journal of Clinical Oncology, Vol. 26, No. 2, 04.2003, p. 171-173.

Research output: Contribution to journalArticle

Mannel, RS, Walker, JL, Gould, N, Scribner, DR, Kamelle, S, Tillmanns, T, McMeekin, DS & Gold, MA 2003, 'Impact of individual physicians on enrollment of patients into clinical trials', American Journal of Clinical Oncology, vol. 26, no. 2, pp. 171-173. https://doi.org/10.1097/00000421-200304000-00014
Mannel, Robert S. ; Walker, Joan L. ; Gould, Natalie ; Scribner, Dennis R. ; Kamelle, Scott ; Tillmanns, Todd ; McMeekin, D. Scott ; Gold, Michael A. / Impact of individual physicians on enrollment of patients into clinical trials. In: American Journal of Clinical Oncology. 2003 ; Vol. 26, No. 2. pp. 171-173.
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