Impact of leucine on energy balance

Liam Mcallan, Paul D. Cotter, Helen M. Roche, Riitta Korpela, Kanishka N. Nilaweera

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Body weight is determined by the balance between energy intake and energy expenditure. When energy intake exceeds energy expenditure, the surplus energy is stored as fat in the adipose tissue, which causes its expansion and may even lead to the development of obesity. Thus, there is a growing interest to develop dietary interventions that could reduce the current obesity epidemic. In this regard, data from a number of in vivo and in vitro studies suggest that the branched-chain amino acid leucine influences energy balance. However, this has not been consistently reported. Here, we review the literature related to the effects of leucine on energy intake, energy expenditure and lipid metabolism as well as its effects on the cellular activity in the brain (hypothalamus) and in peripheral tissues (gastro-intestinal tract, adipose tissue, liver and muscle) regulating the above physiological processes. Moreover, we discuss how obesity may influence the actions of this amino acid.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalJournal of Physiology and Biochemistry
Volume69
Issue number1
DOIs
StatePublished - Mar 1 2013

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Energy balance
Leucine
Energy Metabolism
Energy Intake
Tissue
Obesity
Adipose Tissue
Branched Chain Amino Acids
Physiological Phenomena
Liver
Muscle
Brain
Fats
Lipid Metabolism
Hypothalamus
Amino Acids
Body Weight
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry

Cite this

Mcallan, L., Cotter, P. D., Roche, H. M., Korpela, R., & Nilaweera, K. N. (2013). Impact of leucine on energy balance. Journal of Physiology and Biochemistry, 69(1), 155-163. https://doi.org/10.1007/s13105-012-0170-2

Impact of leucine on energy balance. / Mcallan, Liam; Cotter, Paul D.; Roche, Helen M.; Korpela, Riitta; Nilaweera, Kanishka N.

In: Journal of Physiology and Biochemistry, Vol. 69, No. 1, 01.03.2013, p. 155-163.

Research output: Contribution to journalReview article

Mcallan, L, Cotter, PD, Roche, HM, Korpela, R & Nilaweera, KN 2013, 'Impact of leucine on energy balance', Journal of Physiology and Biochemistry, vol. 69, no. 1, pp. 155-163. https://doi.org/10.1007/s13105-012-0170-2
Mcallan L, Cotter PD, Roche HM, Korpela R, Nilaweera KN. Impact of leucine on energy balance. Journal of Physiology and Biochemistry. 2013 Mar 1;69(1):155-163. https://doi.org/10.1007/s13105-012-0170-2
Mcallan, Liam ; Cotter, Paul D. ; Roche, Helen M. ; Korpela, Riitta ; Nilaweera, Kanishka N. / Impact of leucine on energy balance. In: Journal of Physiology and Biochemistry. 2013 ; Vol. 69, No. 1. pp. 155-163.
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