Impact of prehypertension on carotid artery intima-media thickening: Actual or masked?

Efstathios Manios, Fotios Michas, Georgios Tsivgoulis, Kimon Stamatelopoulos, Georgios Tsagalis, Eleni Koroboki, Eleftheria Alexaki, Christos Papamichael, Konstantinos Vemmos, Nikolaos Zakopoulos

Research output: Contribution to journalArticle

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Abstract

Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects. Methods: A total of 807 subjects with office systolic BP < 140 and diastolic BP < 90 mmHg, underwent 24 h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements. The study population was divided into 3 groups according to office and daytime ABP levels: (1) normotensives: subjects with office BP < 120/80 mmHg and daytime ambulatory BP values within the normal range, (2) actual prehypertensives: individuals with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and daytime ambulatory BP values within the normal range and (3) prehypertensives with masked hypertension (MH): patients with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and elevated daytime ambulatory BP values. Results: Prehypertensive patients with MH had higher (p< 0.01) CCA-IMT values (0.712 mm; 95%CI: 0.698-0.725) than actual prehypertensives (0.649 mm; 95%CI: 0.641-0.656) and normotensives (0.655 mm; 95%CI: 0.641-0.670) even after adjustment for baseline characteristics. Normotensives and actual prehypertensives did not differ significantly regarding CCA-IMT values (p> 0.05). After adjusting for potential confounders, (including demographic characteristics, vascular risk factors, and office BP) prehypertension with MH was independently (p< 0.01) associated with a 0.06 mm increment in CCA-IMT (95%CI: 0.03-0.09). Conclusions: Patients with office BP levels in the prehypertensive range, who also have elevated daytime ABP levels, had higher CCA-IMT values than patients with prehypertension with normal daytime ABP values and normotensive individuals.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalAtherosclerosis
Volume214
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Prehypertension
Carotid Arteries
Carotid Intima-Media Thickness
Blood Pressure
Common Carotid Artery
Demography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Manios, E., Michas, F., Tsivgoulis, G., Stamatelopoulos, K., Tsagalis, G., Koroboki, E., ... Zakopoulos, N. (2011). Impact of prehypertension on carotid artery intima-media thickening: Actual or masked? Atherosclerosis, 214(1), 215-219. https://doi.org/10.1016/j.atherosclerosis.2010.10.032

Impact of prehypertension on carotid artery intima-media thickening : Actual or masked? / Manios, Efstathios; Michas, Fotios; Tsivgoulis, Georgios; Stamatelopoulos, Kimon; Tsagalis, Georgios; Koroboki, Eleni; Alexaki, Eleftheria; Papamichael, Christos; Vemmos, Konstantinos; Zakopoulos, Nikolaos.

In: Atherosclerosis, Vol. 214, No. 1, 01.01.2011, p. 215-219.

Research output: Contribution to journalArticle

Manios, E, Michas, F, Tsivgoulis, G, Stamatelopoulos, K, Tsagalis, G, Koroboki, E, Alexaki, E, Papamichael, C, Vemmos, K & Zakopoulos, N 2011, 'Impact of prehypertension on carotid artery intima-media thickening: Actual or masked?', Atherosclerosis, vol. 214, no. 1, pp. 215-219. https://doi.org/10.1016/j.atherosclerosis.2010.10.032
Manios, Efstathios ; Michas, Fotios ; Tsivgoulis, Georgios ; Stamatelopoulos, Kimon ; Tsagalis, Georgios ; Koroboki, Eleni ; Alexaki, Eleftheria ; Papamichael, Christos ; Vemmos, Konstantinos ; Zakopoulos, Nikolaos. / Impact of prehypertension on carotid artery intima-media thickening : Actual or masked?. In: Atherosclerosis. 2011 ; Vol. 214, No. 1. pp. 215-219.
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abstract = "Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects. Methods: A total of 807 subjects with office systolic BP < 140 and diastolic BP < 90 mmHg, underwent 24 h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements. The study population was divided into 3 groups according to office and daytime ABP levels: (1) normotensives: subjects with office BP < 120/80 mmHg and daytime ambulatory BP values within the normal range, (2) actual prehypertensives: individuals with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and daytime ambulatory BP values within the normal range and (3) prehypertensives with masked hypertension (MH): patients with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and elevated daytime ambulatory BP values. Results: Prehypertensive patients with MH had higher (p< 0.01) CCA-IMT values (0.712 mm; 95{\%}CI: 0.698-0.725) than actual prehypertensives (0.649 mm; 95{\%}CI: 0.641-0.656) and normotensives (0.655 mm; 95{\%}CI: 0.641-0.670) even after adjustment for baseline characteristics. Normotensives and actual prehypertensives did not differ significantly regarding CCA-IMT values (p> 0.05). After adjusting for potential confounders, (including demographic characteristics, vascular risk factors, and office BP) prehypertension with MH was independently (p< 0.01) associated with a 0.06 mm increment in CCA-IMT (95{\%}CI: 0.03-0.09). Conclusions: Patients with office BP levels in the prehypertensive range, who also have elevated daytime ABP levels, had higher CCA-IMT values than patients with prehypertension with normal daytime ABP values and normotensive individuals.",
author = "Efstathios Manios and Fotios Michas and Georgios Tsivgoulis and Kimon Stamatelopoulos and Georgios Tsagalis and Eleni Koroboki and Eleftheria Alexaki and Christos Papamichael and Konstantinos Vemmos and Nikolaos Zakopoulos",
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T2 - Actual or masked?

AU - Manios, Efstathios

AU - Michas, Fotios

AU - Tsivgoulis, Georgios

AU - Stamatelopoulos, Kimon

AU - Tsagalis, Georgios

AU - Koroboki, Eleni

AU - Alexaki, Eleftheria

AU - Papamichael, Christos

AU - Vemmos, Konstantinos

AU - Zakopoulos, Nikolaos

PY - 2011/1/1

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N2 - Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects. Methods: A total of 807 subjects with office systolic BP < 140 and diastolic BP < 90 mmHg, underwent 24 h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements. The study population was divided into 3 groups according to office and daytime ABP levels: (1) normotensives: subjects with office BP < 120/80 mmHg and daytime ambulatory BP values within the normal range, (2) actual prehypertensives: individuals with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and daytime ambulatory BP values within the normal range and (3) prehypertensives with masked hypertension (MH): patients with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and elevated daytime ambulatory BP values. Results: Prehypertensive patients with MH had higher (p< 0.01) CCA-IMT values (0.712 mm; 95%CI: 0.698-0.725) than actual prehypertensives (0.649 mm; 95%CI: 0.641-0.656) and normotensives (0.655 mm; 95%CI: 0.641-0.670) even after adjustment for baseline characteristics. Normotensives and actual prehypertensives did not differ significantly regarding CCA-IMT values (p> 0.05). After adjusting for potential confounders, (including demographic characteristics, vascular risk factors, and office BP) prehypertension with MH was independently (p< 0.01) associated with a 0.06 mm increment in CCA-IMT (95%CI: 0.03-0.09). Conclusions: Patients with office BP levels in the prehypertensive range, who also have elevated daytime ABP levels, had higher CCA-IMT values than patients with prehypertension with normal daytime ABP values and normotensive individuals.

AB - Background: Recent studies have reported that prehypertension is associated with increased values of common carotid artery intima-media thickness (CCA-IMT). The aim of this study was to assess the impact of daytime ambulatory blood pressure (BP) levels on the association of prehypertension with CCA intima-media thickening in prehypertensive subjects. Methods: A total of 807 subjects with office systolic BP < 140 and diastolic BP < 90 mmHg, underwent 24 h ambulatory BP (ABP) monitoring and carotid artery ultrasonographic measurements. The study population was divided into 3 groups according to office and daytime ABP levels: (1) normotensives: subjects with office BP < 120/80 mmHg and daytime ambulatory BP values within the normal range, (2) actual prehypertensives: individuals with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and daytime ambulatory BP values within the normal range and (3) prehypertensives with masked hypertension (MH): patients with office SBP (120-139 mmHg) and/or DBP (80-89 mmHg) and elevated daytime ambulatory BP values. Results: Prehypertensive patients with MH had higher (p< 0.01) CCA-IMT values (0.712 mm; 95%CI: 0.698-0.725) than actual prehypertensives (0.649 mm; 95%CI: 0.641-0.656) and normotensives (0.655 mm; 95%CI: 0.641-0.670) even after adjustment for baseline characteristics. Normotensives and actual prehypertensives did not differ significantly regarding CCA-IMT values (p> 0.05). After adjusting for potential confounders, (including demographic characteristics, vascular risk factors, and office BP) prehypertension with MH was independently (p< 0.01) associated with a 0.06 mm increment in CCA-IMT (95%CI: 0.03-0.09). Conclusions: Patients with office BP levels in the prehypertensive range, who also have elevated daytime ABP levels, had higher CCA-IMT values than patients with prehypertension with normal daytime ABP values and normotensive individuals.

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