Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass

Efstathios Manios, Georgios Tsivgoulis, Eleni Koroboki, Kimon Stamatelopoulos, Christos Papamichael, Savas Toumanidis, Elefterios Stamboulis, Konstantinos Vemmos, Nikolaos Zakopoulos

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background and Purpose-Prehypertension has been recently introduced by JNC 7 as a new blood pressure (BP) category, associated with increased target-organ damage. Subclinical atherosclerosis by means of common artery intima-media thickness (CCA-IMT) has been incompletely investigated in prehypertensive patients. The aim of our study was to assess the extent of CCA-IMT and left ventricular mass (LVM) in prehypertensive adults in comparison to normotensive and untreated hypertensive subjects. Methods-From a total of 5221 consecutive patients screened to our Hypertension Unit we selected 896 consecutive individuals according to prespecified inclusion criteria, who underwent 24-hour ambulatory BP monitoring, carotid artery ultrasonographic, and echocardiographic measurements. Patients who received antihypertensive treatment during the BP monitoring were excluded. According to the office BP levels, patients were divided into 3 subgroups: normotensives (office BP < 120/80 mmHg), prehypertensives (120/80 mmHg≤office BP≤ 140/90 mmHg), and hypertensives (office BP ≥ 140/90 mm Hg). Statistical analyses were performed by means of 1-way ANOVA, χ2 test, and ANCOVA. Results-According to the office BP levels, the distribution of the study population was: normotensives (14.4%), prehypertensives (23.7%), and hypertensives (61.9%). Prehypertensive patients had higher CCA-IMT (P=0.038) and LVM (P=0.030) values than normotensive subjects, even after adjustment for baseline characteristics. Greater CCA-IMT values were observed in hypertensive patients in comparison to prehypertensives (P=0.002). Conclusions-Prehypertensive patients had higher CCA-IMT and LVM than their normotensive counterparts. Prehypertension status is cross-sectionally associated with subclinical atherosclerosis and target-organ damage.

Original languageEnglish (US)
Pages (from-to)1515-1518
Number of pages4
JournalStroke
Volume40
Issue number4
DOIs
StatePublished - Apr 1 2009
Externally publishedYes

Fingerprint

Prehypertension
Carotid Intima-Media Thickness
Common Carotid Artery
Blood Pressure
Atherosclerosis
Ambulatory Blood Pressure Monitoring
Carotid Arteries
Antihypertensive Agents
Analysis of Variance
Arteries
Demography
Hypertension

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Manios, E., Tsivgoulis, G., Koroboki, E., Stamatelopoulos, K., Papamichael, C., Toumanidis, S., ... Zakopoulos, N. (2009). Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass. Stroke, 40(4), 1515-1518. https://doi.org/10.1161/STROKEAHA.108.528174

Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass. / Manios, Efstathios; Tsivgoulis, Georgios; Koroboki, Eleni; Stamatelopoulos, Kimon; Papamichael, Christos; Toumanidis, Savas; Stamboulis, Elefterios; Vemmos, Konstantinos; Zakopoulos, Nikolaos.

In: Stroke, Vol. 40, No. 4, 01.04.2009, p. 1515-1518.

Research output: Contribution to journalArticle

Manios, E, Tsivgoulis, G, Koroboki, E, Stamatelopoulos, K, Papamichael, C, Toumanidis, S, Stamboulis, E, Vemmos, K & Zakopoulos, N 2009, 'Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass', Stroke, vol. 40, no. 4, pp. 1515-1518. https://doi.org/10.1161/STROKEAHA.108.528174
Manios, Efstathios ; Tsivgoulis, Georgios ; Koroboki, Eleni ; Stamatelopoulos, Kimon ; Papamichael, Christos ; Toumanidis, Savas ; Stamboulis, Elefterios ; Vemmos, Konstantinos ; Zakopoulos, Nikolaos. / Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass. In: Stroke. 2009 ; Vol. 40, No. 4. pp. 1515-1518.
@article{c0c0d51d258e4bff90bea47a2281f016,
title = "Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass",
abstract = "Background and Purpose-Prehypertension has been recently introduced by JNC 7 as a new blood pressure (BP) category, associated with increased target-organ damage. Subclinical atherosclerosis by means of common artery intima-media thickness (CCA-IMT) has been incompletely investigated in prehypertensive patients. The aim of our study was to assess the extent of CCA-IMT and left ventricular mass (LVM) in prehypertensive adults in comparison to normotensive and untreated hypertensive subjects. Methods-From a total of 5221 consecutive patients screened to our Hypertension Unit we selected 896 consecutive individuals according to prespecified inclusion criteria, who underwent 24-hour ambulatory BP monitoring, carotid artery ultrasonographic, and echocardiographic measurements. Patients who received antihypertensive treatment during the BP monitoring were excluded. According to the office BP levels, patients were divided into 3 subgroups: normotensives (office BP < 120/80 mmHg), prehypertensives (120/80 mmHg≤office BP≤ 140/90 mmHg), and hypertensives (office BP ≥ 140/90 mm Hg). Statistical analyses were performed by means of 1-way ANOVA, χ2 test, and ANCOVA. Results-According to the office BP levels, the distribution of the study population was: normotensives (14.4{\%}), prehypertensives (23.7{\%}), and hypertensives (61.9{\%}). Prehypertensive patients had higher CCA-IMT (P=0.038) and LVM (P=0.030) values than normotensive subjects, even after adjustment for baseline characteristics. Greater CCA-IMT values were observed in hypertensive patients in comparison to prehypertensives (P=0.002). Conclusions-Prehypertensive patients had higher CCA-IMT and LVM than their normotensive counterparts. Prehypertension status is cross-sectionally associated with subclinical atherosclerosis and target-organ damage.",
author = "Efstathios Manios and Georgios Tsivgoulis and Eleni Koroboki and Kimon Stamatelopoulos and Christos Papamichael and Savas Toumanidis and Elefterios Stamboulis and Konstantinos Vemmos and Nikolaos Zakopoulos",
year = "2009",
month = "4",
day = "1",
doi = "10.1161/STROKEAHA.108.528174",
language = "English (US)",
volume = "40",
pages = "1515--1518",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Impact of prehypertension on common carotid artery intima-media thickness and left ventricular mass

AU - Manios, Efstathios

AU - Tsivgoulis, Georgios

AU - Koroboki, Eleni

AU - Stamatelopoulos, Kimon

AU - Papamichael, Christos

AU - Toumanidis, Savas

AU - Stamboulis, Elefterios

AU - Vemmos, Konstantinos

AU - Zakopoulos, Nikolaos

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Background and Purpose-Prehypertension has been recently introduced by JNC 7 as a new blood pressure (BP) category, associated with increased target-organ damage. Subclinical atherosclerosis by means of common artery intima-media thickness (CCA-IMT) has been incompletely investigated in prehypertensive patients. The aim of our study was to assess the extent of CCA-IMT and left ventricular mass (LVM) in prehypertensive adults in comparison to normotensive and untreated hypertensive subjects. Methods-From a total of 5221 consecutive patients screened to our Hypertension Unit we selected 896 consecutive individuals according to prespecified inclusion criteria, who underwent 24-hour ambulatory BP monitoring, carotid artery ultrasonographic, and echocardiographic measurements. Patients who received antihypertensive treatment during the BP monitoring were excluded. According to the office BP levels, patients were divided into 3 subgroups: normotensives (office BP < 120/80 mmHg), prehypertensives (120/80 mmHg≤office BP≤ 140/90 mmHg), and hypertensives (office BP ≥ 140/90 mm Hg). Statistical analyses were performed by means of 1-way ANOVA, χ2 test, and ANCOVA. Results-According to the office BP levels, the distribution of the study population was: normotensives (14.4%), prehypertensives (23.7%), and hypertensives (61.9%). Prehypertensive patients had higher CCA-IMT (P=0.038) and LVM (P=0.030) values than normotensive subjects, even after adjustment for baseline characteristics. Greater CCA-IMT values were observed in hypertensive patients in comparison to prehypertensives (P=0.002). Conclusions-Prehypertensive patients had higher CCA-IMT and LVM than their normotensive counterparts. Prehypertension status is cross-sectionally associated with subclinical atherosclerosis and target-organ damage.

AB - Background and Purpose-Prehypertension has been recently introduced by JNC 7 as a new blood pressure (BP) category, associated with increased target-organ damage. Subclinical atherosclerosis by means of common artery intima-media thickness (CCA-IMT) has been incompletely investigated in prehypertensive patients. The aim of our study was to assess the extent of CCA-IMT and left ventricular mass (LVM) in prehypertensive adults in comparison to normotensive and untreated hypertensive subjects. Methods-From a total of 5221 consecutive patients screened to our Hypertension Unit we selected 896 consecutive individuals according to prespecified inclusion criteria, who underwent 24-hour ambulatory BP monitoring, carotid artery ultrasonographic, and echocardiographic measurements. Patients who received antihypertensive treatment during the BP monitoring were excluded. According to the office BP levels, patients were divided into 3 subgroups: normotensives (office BP < 120/80 mmHg), prehypertensives (120/80 mmHg≤office BP≤ 140/90 mmHg), and hypertensives (office BP ≥ 140/90 mm Hg). Statistical analyses were performed by means of 1-way ANOVA, χ2 test, and ANCOVA. Results-According to the office BP levels, the distribution of the study population was: normotensives (14.4%), prehypertensives (23.7%), and hypertensives (61.9%). Prehypertensive patients had higher CCA-IMT (P=0.038) and LVM (P=0.030) values than normotensive subjects, even after adjustment for baseline characteristics. Greater CCA-IMT values were observed in hypertensive patients in comparison to prehypertensives (P=0.002). Conclusions-Prehypertensive patients had higher CCA-IMT and LVM than their normotensive counterparts. Prehypertension status is cross-sectionally associated with subclinical atherosclerosis and target-organ damage.

UR - http://www.scopus.com/inward/record.url?scp=65249115259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249115259&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.108.528174

DO - 10.1161/STROKEAHA.108.528174

M3 - Article

VL - 40

SP - 1515

EP - 1518

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 4

ER -