Impact of renal surgery for cortical neoplasms on lipid metabolism

Aditya Bagrodia, Ryan P. Kopp, Reza Mehrazin, Hak J. Lee, Michael A. Liss, Ramzi Jabaji, Christopher J. Kane, Robert Wake, Anthony Patterson, Jim Wan, Ithaar H. Derweesh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To examine the incidence of and risk factors for development of hyperlipidaemia in patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN) for renal cortical neoplasms, as hyperlipidaemia is a major source of morbidity in chronic kidney disease (CKD). Patients and Methods We conducted a two-centre retrospective analysis of 905 patients (mean age 57.5 years, mean follow-up 78 months), who underwent RN (n = 610) or PN (n = 295) between July 1987 and June 2007. Demographics, preoperative and postoperative hyperlipidaemia were recorded. De novo hyperlipidaemia was defined as that ocurring ≥6 months after surgery in cases where laboratory values met National Cholesterol Education Program Adult Treatment Panel III definitions. The Kaplan-Meier method was used to assess freedom from de novo hyperlipidaemia. Multivariable analysis was conducted to determine the risk factors for de novo hyperlipidaemia. Results There were no significant differences with respect to demographics, preoperative glomerular filtration rate (GFR) <60 mL/min/1.73 m 2 (P = 0.123) and hyperlipidaemia (P = 0.144). Tumour size (cm) was significantly larger in the RN group vs the PN group (7.0 vs 3.7; P < 0.001). Significantly greater postoperative GFR <60 mL/min/1.73 m 2 was noted in the RN group (45.7 vs 18%, P < 0.001). Significantly, more de novo hyperlipidaemia developed in the RN group than in the PN group (23 vs 6.4%; P < 0.001). The mean time to development of hyperlipidaemia was longer for PN than for RN (54 vs 44 months; P = 0.03). Five-year freedom from de novo hyperlipidaemia probability was 76% for RN vs 96% for PN (P < 0.001). Multivariable analysis showed that RN (odds ratio [OR] 2.93; P = 0.0107), preoperative GFR <60 mL/min/1.73 m 2 (OR 1.98; P = 0.037) and postoperative GFR <60 mL/min/1.73 m 2 (OR 7.89; P < 0.001) were factors associated with hyperlipidaemia development. Conclusion Patients who underwent RN had a significantly higher incidence of and shorter time to development of de novo hyperlipidaemia. RN and pre- and postoperative eGFR <60 mL/min/1.73 m 2 were associated with development of hyperlipidaemia. Further follow-up and prospective investigation are necessary to confirm these findings.

Original languageEnglish (US)
Pages (from-to)837-843
Number of pages7
JournalBJU International
Volume114
Issue number6
DOIs
StatePublished - Dec 1 2014

Fingerprint

Nephrectomy
Lipid Metabolism
Hyperlipidemias
Kidney
Neoplasms
Glomerular Filtration Rate
Odds Ratio
Demography
Kidney Neoplasms
Incidence
Chronic Renal Insufficiency

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Bagrodia, A., Kopp, R. P., Mehrazin, R., Lee, H. J., Liss, M. A., Jabaji, R., ... Derweesh, I. H. (2014). Impact of renal surgery for cortical neoplasms on lipid metabolism. BJU International, 114(6), 837-843. https://doi.org/10.1111/bju.12744

Impact of renal surgery for cortical neoplasms on lipid metabolism. / Bagrodia, Aditya; Kopp, Ryan P.; Mehrazin, Reza; Lee, Hak J.; Liss, Michael A.; Jabaji, Ramzi; Kane, Christopher J.; Wake, Robert; Patterson, Anthony; Wan, Jim; Derweesh, Ithaar H.

In: BJU International, Vol. 114, No. 6, 01.12.2014, p. 837-843.

Research output: Contribution to journalArticle

Bagrodia, A, Kopp, RP, Mehrazin, R, Lee, HJ, Liss, MA, Jabaji, R, Kane, CJ, Wake, R, Patterson, A, Wan, J & Derweesh, IH 2014, 'Impact of renal surgery for cortical neoplasms on lipid metabolism', BJU International, vol. 114, no. 6, pp. 837-843. https://doi.org/10.1111/bju.12744
Bagrodia A, Kopp RP, Mehrazin R, Lee HJ, Liss MA, Jabaji R et al. Impact of renal surgery for cortical neoplasms on lipid metabolism. BJU International. 2014 Dec 1;114(6):837-843. https://doi.org/10.1111/bju.12744
Bagrodia, Aditya ; Kopp, Ryan P. ; Mehrazin, Reza ; Lee, Hak J. ; Liss, Michael A. ; Jabaji, Ramzi ; Kane, Christopher J. ; Wake, Robert ; Patterson, Anthony ; Wan, Jim ; Derweesh, Ithaar H. / Impact of renal surgery for cortical neoplasms on lipid metabolism. In: BJU International. 2014 ; Vol. 114, No. 6. pp. 837-843.
@article{4e6ebfec516943f590b58c9bd0b297b2,
title = "Impact of renal surgery for cortical neoplasms on lipid metabolism",
abstract = "Objective To examine the incidence of and risk factors for development of hyperlipidaemia in patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN) for renal cortical neoplasms, as hyperlipidaemia is a major source of morbidity in chronic kidney disease (CKD). Patients and Methods We conducted a two-centre retrospective analysis of 905 patients (mean age 57.5 years, mean follow-up 78 months), who underwent RN (n = 610) or PN (n = 295) between July 1987 and June 2007. Demographics, preoperative and postoperative hyperlipidaemia were recorded. De novo hyperlipidaemia was defined as that ocurring ≥6 months after surgery in cases where laboratory values met National Cholesterol Education Program Adult Treatment Panel III definitions. The Kaplan-Meier method was used to assess freedom from de novo hyperlipidaemia. Multivariable analysis was conducted to determine the risk factors for de novo hyperlipidaemia. Results There were no significant differences with respect to demographics, preoperative glomerular filtration rate (GFR) <60 mL/min/1.73 m 2 (P = 0.123) and hyperlipidaemia (P = 0.144). Tumour size (cm) was significantly larger in the RN group vs the PN group (7.0 vs 3.7; P < 0.001). Significantly greater postoperative GFR <60 mL/min/1.73 m 2 was noted in the RN group (45.7 vs 18{\%}, P < 0.001). Significantly, more de novo hyperlipidaemia developed in the RN group than in the PN group (23 vs 6.4{\%}; P < 0.001). The mean time to development of hyperlipidaemia was longer for PN than for RN (54 vs 44 months; P = 0.03). Five-year freedom from de novo hyperlipidaemia probability was 76{\%} for RN vs 96{\%} for PN (P < 0.001). Multivariable analysis showed that RN (odds ratio [OR] 2.93; P = 0.0107), preoperative GFR <60 mL/min/1.73 m 2 (OR 1.98; P = 0.037) and postoperative GFR <60 mL/min/1.73 m 2 (OR 7.89; P < 0.001) were factors associated with hyperlipidaemia development. Conclusion Patients who underwent RN had a significantly higher incidence of and shorter time to development of de novo hyperlipidaemia. RN and pre- and postoperative eGFR <60 mL/min/1.73 m 2 were associated with development of hyperlipidaemia. Further follow-up and prospective investigation are necessary to confirm these findings.",
author = "Aditya Bagrodia and Kopp, {Ryan P.} and Reza Mehrazin and Lee, {Hak J.} and Liss, {Michael A.} and Ramzi Jabaji and Kane, {Christopher J.} and Robert Wake and Anthony Patterson and Jim Wan and Derweesh, {Ithaar H.}",
year = "2014",
month = "12",
day = "1",
doi = "10.1111/bju.12744",
language = "English (US)",
volume = "114",
pages = "837--843",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Impact of renal surgery for cortical neoplasms on lipid metabolism

AU - Bagrodia, Aditya

AU - Kopp, Ryan P.

AU - Mehrazin, Reza

AU - Lee, Hak J.

AU - Liss, Michael A.

AU - Jabaji, Ramzi

AU - Kane, Christopher J.

AU - Wake, Robert

AU - Patterson, Anthony

AU - Wan, Jim

AU - Derweesh, Ithaar H.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objective To examine the incidence of and risk factors for development of hyperlipidaemia in patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN) for renal cortical neoplasms, as hyperlipidaemia is a major source of morbidity in chronic kidney disease (CKD). Patients and Methods We conducted a two-centre retrospective analysis of 905 patients (mean age 57.5 years, mean follow-up 78 months), who underwent RN (n = 610) or PN (n = 295) between July 1987 and June 2007. Demographics, preoperative and postoperative hyperlipidaemia were recorded. De novo hyperlipidaemia was defined as that ocurring ≥6 months after surgery in cases where laboratory values met National Cholesterol Education Program Adult Treatment Panel III definitions. The Kaplan-Meier method was used to assess freedom from de novo hyperlipidaemia. Multivariable analysis was conducted to determine the risk factors for de novo hyperlipidaemia. Results There were no significant differences with respect to demographics, preoperative glomerular filtration rate (GFR) <60 mL/min/1.73 m 2 (P = 0.123) and hyperlipidaemia (P = 0.144). Tumour size (cm) was significantly larger in the RN group vs the PN group (7.0 vs 3.7; P < 0.001). Significantly greater postoperative GFR <60 mL/min/1.73 m 2 was noted in the RN group (45.7 vs 18%, P < 0.001). Significantly, more de novo hyperlipidaemia developed in the RN group than in the PN group (23 vs 6.4%; P < 0.001). The mean time to development of hyperlipidaemia was longer for PN than for RN (54 vs 44 months; P = 0.03). Five-year freedom from de novo hyperlipidaemia probability was 76% for RN vs 96% for PN (P < 0.001). Multivariable analysis showed that RN (odds ratio [OR] 2.93; P = 0.0107), preoperative GFR <60 mL/min/1.73 m 2 (OR 1.98; P = 0.037) and postoperative GFR <60 mL/min/1.73 m 2 (OR 7.89; P < 0.001) were factors associated with hyperlipidaemia development. Conclusion Patients who underwent RN had a significantly higher incidence of and shorter time to development of de novo hyperlipidaemia. RN and pre- and postoperative eGFR <60 mL/min/1.73 m 2 were associated with development of hyperlipidaemia. Further follow-up and prospective investigation are necessary to confirm these findings.

AB - Objective To examine the incidence of and risk factors for development of hyperlipidaemia in patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN) for renal cortical neoplasms, as hyperlipidaemia is a major source of morbidity in chronic kidney disease (CKD). Patients and Methods We conducted a two-centre retrospective analysis of 905 patients (mean age 57.5 years, mean follow-up 78 months), who underwent RN (n = 610) or PN (n = 295) between July 1987 and June 2007. Demographics, preoperative and postoperative hyperlipidaemia were recorded. De novo hyperlipidaemia was defined as that ocurring ≥6 months after surgery in cases where laboratory values met National Cholesterol Education Program Adult Treatment Panel III definitions. The Kaplan-Meier method was used to assess freedom from de novo hyperlipidaemia. Multivariable analysis was conducted to determine the risk factors for de novo hyperlipidaemia. Results There were no significant differences with respect to demographics, preoperative glomerular filtration rate (GFR) <60 mL/min/1.73 m 2 (P = 0.123) and hyperlipidaemia (P = 0.144). Tumour size (cm) was significantly larger in the RN group vs the PN group (7.0 vs 3.7; P < 0.001). Significantly greater postoperative GFR <60 mL/min/1.73 m 2 was noted in the RN group (45.7 vs 18%, P < 0.001). Significantly, more de novo hyperlipidaemia developed in the RN group than in the PN group (23 vs 6.4%; P < 0.001). The mean time to development of hyperlipidaemia was longer for PN than for RN (54 vs 44 months; P = 0.03). Five-year freedom from de novo hyperlipidaemia probability was 76% for RN vs 96% for PN (P < 0.001). Multivariable analysis showed that RN (odds ratio [OR] 2.93; P = 0.0107), preoperative GFR <60 mL/min/1.73 m 2 (OR 1.98; P = 0.037) and postoperative GFR <60 mL/min/1.73 m 2 (OR 7.89; P < 0.001) were factors associated with hyperlipidaemia development. Conclusion Patients who underwent RN had a significantly higher incidence of and shorter time to development of de novo hyperlipidaemia. RN and pre- and postoperative eGFR <60 mL/min/1.73 m 2 were associated with development of hyperlipidaemia. Further follow-up and prospective investigation are necessary to confirm these findings.

UR - http://www.scopus.com/inward/record.url?scp=84911401004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84911401004&partnerID=8YFLogxK

U2 - 10.1111/bju.12744

DO - 10.1111/bju.12744

M3 - Article

VL - 114

SP - 837

EP - 843

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 6

ER -