Impaired endothelial function in preadolescent children with type 1 diabetes

Ghufran S. Babar, Hanaa Zidan, Michael E. Widlansky, Das Emon, Raymond G. Hoffmann, Marwan Daoud, Ramin Alemzadeh

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE - We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS - We studied 21 type 1 diabetic children (aged 8.3±0.3 years with diabetes duration of 4.3±0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA 1c, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS - Type 1 diabetic children had higher FPG (173.4±7.9 mg/dL vs. 81.40±1.7mg/dL; P < 0.0001), HbA 1c (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS - Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children.

Original languageEnglish (US)
Pages (from-to)681-685
Number of pages5
JournalDiabetes Care
Volume34
Issue number3
DOIs
StatePublished - Mar 1 2011
Externally publishedYes

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Type 1 Diabetes Mellitus
Carotid Intima-Media Thickness
Dilatation
Blood Vessels
Brachial Artery
Erythrocytes
Homocysteine
Folic Acid
C-Reactive Protein
Fibrinogen
Fasting
Research Design
Inflammation
Glucose
Siblings
Biomarkers
Lipids

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Babar, G. S., Zidan, H., Widlansky, M. E., Emon, D., Hoffmann, R. G., Daoud, M., & Alemzadeh, R. (2011). Impaired endothelial function in preadolescent children with type 1 diabetes. Diabetes Care, 34(3), 681-685. https://doi.org/10.2337/dc10-2134

Impaired endothelial function in preadolescent children with type 1 diabetes. / Babar, Ghufran S.; Zidan, Hanaa; Widlansky, Michael E.; Emon, Das; Hoffmann, Raymond G.; Daoud, Marwan; Alemzadeh, Ramin.

In: Diabetes Care, Vol. 34, No. 3, 01.03.2011, p. 681-685.

Research output: Contribution to journalArticle

Babar, GS, Zidan, H, Widlansky, ME, Emon, D, Hoffmann, RG, Daoud, M & Alemzadeh, R 2011, 'Impaired endothelial function in preadolescent children with type 1 diabetes', Diabetes Care, vol. 34, no. 3, pp. 681-685. https://doi.org/10.2337/dc10-2134
Babar GS, Zidan H, Widlansky ME, Emon D, Hoffmann RG, Daoud M et al. Impaired endothelial function in preadolescent children with type 1 diabetes. Diabetes Care. 2011 Mar 1;34(3):681-685. https://doi.org/10.2337/dc10-2134
Babar, Ghufran S. ; Zidan, Hanaa ; Widlansky, Michael E. ; Emon, Das ; Hoffmann, Raymond G. ; Daoud, Marwan ; Alemzadeh, Ramin. / Impaired endothelial function in preadolescent children with type 1 diabetes. In: Diabetes Care. 2011 ; Vol. 34, No. 3. pp. 681-685.
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abstract = "OBJECTIVE - We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS - We studied 21 type 1 diabetic children (aged 8.3±0.3 years with diabetes duration of 4.3±0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA 1c, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD{\%}) measurements using high-resolution vascular ultrasound. RESULTS - Type 1 diabetic children had higher FPG (173.4±7.9 mg/dL vs. 81.40±1.7mg/dL; P < 0.0001), HbA 1c (8.0 ± 0.2{\%} vs. 5.0 ± 0.1{\%}; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD{\%} than control children (7.1 ± 0.8{\%} vs. 9.8 ± 1.1{\%}; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS - Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children.",
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AU - Daoud, Marwan

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N2 - OBJECTIVE - We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS - We studied 21 type 1 diabetic children (aged 8.3±0.3 years with diabetes duration of 4.3±0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA 1c, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS - Type 1 diabetic children had higher FPG (173.4±7.9 mg/dL vs. 81.40±1.7mg/dL; P < 0.0001), HbA 1c (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS - Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children.

AB - OBJECTIVE - We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS - We studied 21 type 1 diabetic children (aged 8.3±0.3 years with diabetes duration of 4.3±0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA 1c, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS - Type 1 diabetic children had higher FPG (173.4±7.9 mg/dL vs. 81.40±1.7mg/dL; P < 0.0001), HbA 1c (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS - Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children.

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