Impaired spatial learning in the APPSwe + PSEN1ΔE9 bigenic mouse model of Alzheimer's disease

R. S. Reiserer, F. E. Harrison, D. C. Syverud, Michael Mcdonald

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Mice co-expressing the Swedish amyloid precursor protein mutation (APP Swe) and exon 9 deletion (ΔE9) of the PSEN1 gene begin to develop amyloid plaques at 6-7 months of age. We demonstrate here a spatial learning deficit in 7-month-old APPSwe + PSEN1ΔE9 bigenic mice using an adaptation of the Barnes maze. Mice were first trained on a cued target followed by a hidden-target condition. Although bigenic mice quickly learned the cued-target version of the task, they were significantly impaired when switched to the hidden-target version. In contrast, a separate group of double-transgenic mice trained first on the spatial hidden-target version of the task were unimpaired relative to wild-type controls. We propose that processes such as general rule learning, context learning and exploratory habituation exert a greater influence when the testing environment is novel and overshadow the spatial memory deficit in naive bigenic mice. However, when cued-target training is conducted first, these processes habituate and the spatial learning deficit is unmasked. Seven-month-old APPSwe + PSEN1ΔE9 mice were unimpaired on tests of memory that did not involve learning the rules governing spatial associations.

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalGenes, Brain and Behavior
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2007

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Alzheimer Disease
Learning
Amyloid beta-Protein Precursor
Amyloid Plaques
Memory Disorders
Gene Deletion
Transgenic Mice
Spatial Learning
Exons
Mutation

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Impaired spatial learning in the APPSwe + PSEN1ΔE9 bigenic mouse model of Alzheimer's disease. / Reiserer, R. S.; Harrison, F. E.; Syverud, D. C.; Mcdonald, Michael.

In: Genes, Brain and Behavior, Vol. 6, No. 1, 01.02.2007, p. 54-65.

Research output: Contribution to journalArticle

Reiserer, R. S. ; Harrison, F. E. ; Syverud, D. C. ; Mcdonald, Michael. / Impaired spatial learning in the APPSwe + PSEN1ΔE9 bigenic mouse model of Alzheimer's disease. In: Genes, Brain and Behavior. 2007 ; Vol. 6, No. 1. pp. 54-65.
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