Implications for the role of endogenous nitric oxide inhibitors in hemodialysis hypotension

Ellen S. Kang, Sergio R. Acchiardo, Andrew Kang

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Hypotensive episodes during hemodialysis in patients with end-stage renal disease in the absence of inadequate maintenance of the plasma volume, pre-existence of cardiovascular disease, or autonomic nervous system dysfunction is accompanied by increase in the plasma concentrations of the end-products of nitric oxide metabolism, above the levels expected based on the reduction of urea. Factors that can influence the synthesis of nitric oxide or the regulation of the effects of this free radical in patients with chronic renal failure are reviewed. Convergence of these factors and their interactions during the hemodialysis procedure are discussed as the basis for the generation of excessive amounts of nitric oxide that serves as an important contributing factor in the development of symptomatic hypotension.

Original languageEnglish (US)
Pages (from-to)341-365
Number of pages25
JournalFree Radical Research
Volume35
Issue number4
DOIs
StatePublished - Jan 1 2001

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Hypotension
Renal Dialysis
Nitric Oxide
Chronic Kidney Failure
Plasmas
Plasma Volume
Autonomic Nervous System
Neurology
Metabolism
Free Radicals
Urea
Cardiovascular Diseases
Maintenance

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Implications for the role of endogenous nitric oxide inhibitors in hemodialysis hypotension. / Kang, Ellen S.; Acchiardo, Sergio R.; Kang, Andrew.

In: Free Radical Research, Vol. 35, No. 4, 01.01.2001, p. 341-365.

Research output: Contribution to journalReview article

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